Frydman-Marom Anat, Rechter Meirav, Shefler Irit, Bram Yaron, Shalev Deborah E, Gazit Ehud
Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel.
Angew Chem Int Ed Engl. 2009;48(11):1981-6. doi: 10.1002/anie.200802123.
A rationally designed oligomerization inhibitor interacts with early intermediate assemblies of amyloid-beta polypeptide (Abeta) through the aromatic elements and inhibits their assembly into the toxic oligomers that cause Alzheimer's disease by a unique C(alpha)-methylation beta-breakage strategy. The electrostatic potential of the low-energy conformation of the dipeptide inhibitor bound to Abeta is shown.
一种经过合理设计的寡聚化抑制剂通过芳香族元素与β淀粉样多肽（Aβ）的早期中间聚集体相互作用，并通过独特的α-甲基化β断裂策略抑制其组装成导致阿尔茨海默病的有毒寡聚体。展示了与Aβ结合的二肽抑制剂低能构象的静电势。
