Xu S, Shi F, Wu H
Shanghai Institute of Animal Parasitology, Chinese Academy of Agricultural Sciences.
Parasitology. 1991 Feb;102 Pt 1:45-7. doi: 10.1017/s0031182000060327.
Experiments were conducted in guinea-pigs to elucidate the parameters affecting the development of protective immunity against Schistosoma japonicum induced by a cryopreserved, irradiated schistosomula vaccine such as the number of immunizations, route of injection and the use of adjuvants. Results obtained indicated that the cryopreserved, irradiated schistosomula vaccine was effective by either intradermal or intramuscular injection. One intradermal injection with BCG adjuvant resulted in an average worm reduction of 50 x 24%, only a little lower than that of a non-cryopreserved, irradiated vaccine, 53 x 55%, with no statistically significant difference between the two. By intramuscular injection the worm reduction was lower (max. 40%) whether given with or without adjuvants or in 1 or 2 injections.
在豚鼠身上进行了实验，以阐明影响由冷冻保存、辐照的童虫疫苗诱导的针对日本血吸虫的保护性免疫发展的参数，如免疫次数、注射途径和佐剂的使用。获得的结果表明，冷冻保存、辐照的童虫疫苗通过皮内或肌肉注射都是有效的。一次皮内注射卡介苗佐剂平均减虫率为50×24%，仅略低于未冷冻保存、辐照的疫苗（53×55%），两者之间无统计学显著差异。通过肌肉注射，无论是否使用佐剂或注射1次或2次，减虫率都较低（最高40%）。
