Paiement J, Dominguez J M, Guénette A, Roy L
Département d'anatomie, Faculté de médecine, Université de Montréal, Québec, Canada.
Biochem Biophys Res Commun. 1991 May 15;176(3):1494-500. doi: 10.1016/0006-291x(91)90456-h.
Rough microsomes were isolated from homogenates of livers of rats bearing hepatomas as well as from homogenates of livers of rats 24 and 48 h after partial hepatectomy. When incubated in the presence of GTP in a cell-free system to assay membrane fusion these membranes were observed to have a greater capacity (1.4 to 5 fold) for GTP-dependent fusion than homologous membranes from control non-proliferating liver tissue. The enhanced GTP-dependent membrane fusion may reflect changes in membrane properties related to cell proliferation.
