Lang S H, Frame F M, Collins A T
YCR Cancer Research Unit, Department of Biology, University of York, UK.
J Pathol. 2009 Jan;217(2):299-306. doi: 10.1002/path.2478.
Despite the discovery over 60 years ago by Huggins and Hodges that prostate cancers respond to androgen deprivation therapy, hormone-refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours originate from undifferentiated stem cell-like cells coexisting within a heterogeneous tumour mass that drive tumour formation, maintain tumour homeostasis and initiate metastases. This review focuses upon current evidence for prostate cancer stem cells, addressing the identification and properties of both normal and transformed prostate stem cells.
尽管60多年前哈金斯和霍奇斯就发现前列腺癌对雄激素剥夺疗法有反应，但激素难治性前列腺癌仍然是一个重大的临床挑战。现在有越来越多的证据表明，实体瘤起源于未分化的干细胞样细胞，这些细胞共存于异质性肿瘤块中，驱动肿瘤形成、维持肿瘤内环境稳定并引发转移。这篇综述聚焦于前列腺癌干细胞的现有证据，探讨正常和转化前列腺干细胞的识别及特性。
