• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Amorphous pharmaceutical solids: characterization, stabilization, and development of marketable formulations of poorly soluble drugs with improved oral absorption.

作者信息

Gao Ping

出版信息

Mol Pharm. 2008 Nov-Dec;5(6):903-4. doi: 10.1021/mp800203k.

DOI:10.1021/mp800203k
PMID:19040385
Abstract
摘要

相似文献

1
Amorphous pharmaceutical solids: characterization, stabilization, and development of marketable formulations of poorly soluble drugs with improved oral absorption.无定形药物固体:难溶性药物具有改善口服吸收的可销售制剂的表征、稳定化及开发
Mol Pharm. 2008 Nov-Dec;5(6):903-4. doi: 10.1021/mp800203k.
2
Coaxial electrospray formulations for improving oral absorption of a poorly water-soluble drug.同轴电喷雾制剂改善难溶性药物口服吸收的研究
Mol Pharm. 2011 Jun 6;8(3):807-13. doi: 10.1021/mp100401d. Epub 2011 Mar 25.
3
Physical stabilization of low-molecular-weight amorphous drugs in the solid state: a material science approach.
Ther Deliv. 2014 Jul;5(7):817-41. doi: 10.4155/tde.14.39.
4
Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations.将难溶性药物转化为亲脂性离子液体可提高基于脂质制剂的口服药物暴露量。
Mol Pharm. 2015 Jun 1;12(6):1980-91. doi: 10.1021/mp500790t. Epub 2015 May 5.
5
Amino acids as co-amorphous stabilizers for poorly water soluble drugs--Part 1: preparation, stability and dissolution enhancement.氨基酸作为低水溶解性药物的共无定形稳定剂——第 1 部分:制备、稳定性和溶出度的提高。
Eur J Pharm Biopharm. 2013 Nov;85(3 Pt B):873-81. doi: 10.1016/j.ejpb.2013.03.014. Epub 2013 Mar 26.
6
Oral lipid-based formulations.口服脂质体制剂。
Adv Drug Deliv Rev. 2007 Jul 30;59(7):667-76. doi: 10.1016/j.addr.2007.05.006. Epub 2007 May 26.
7
In silico prediction of the solubility advantage for amorphous drugs - Are there property-based rules for drug discovery and early pharmaceutical development?非晶态药物溶解度优势的计算机模拟预测——药物发现和早期药物研发中是否存在基于性质的规则?
Eur J Pharm Sci. 2013 Feb 14;48(3):554-62. doi: 10.1016/j.ejps.2012.11.015. Epub 2012 Dec 20.
8
Supersaturation-nucleation behavior of poorly soluble drugs and its impact on the oral absorption of drugs in thermodynamically high-energy forms.低溶解度药物的过饱和-成核行为及其对高热力学能量形式药物口服吸收的影响。
J Pharm Sci. 2012 Jan;101(1):214-22. doi: 10.1002/jps.22760. Epub 2011 Sep 14.
9
Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs.固体脂质纳米粒(SLNs)用于提高难溶性药物的口服生物利用度。
J Pharm Pharmacol. 2004 Dec;56(12):1527-35. doi: 10.1211/0022357044959.
10
Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration.将液体和半固体制剂封装于口服胶囊中的挑战与机遇。
Adv Drug Deliv Rev. 2008 Mar 17;60(6):747-56. doi: 10.1016/j.addr.2007.09.009. Epub 2007 Nov 9.

引用本文的文献

1
Investigation of Molecular Weight, Polymer Concentration and Process Parameters Factors on the Sustained Release of the Anti-Multiple-Sclerosis Agent Teriflunomide from Poly(-caprolactone) Electrospun Nanofibrous Matrices.分子量、聚合物浓度及工艺参数对抗多发性硬化症药物特立氟胺从聚(己内酯)电纺纳米纤维基质中持续释放影响的研究
Pharmaceutics. 2022 Aug 14;14(8):1693. doi: 10.3390/pharmaceutics14081693.
2
Using X-ray Diffraction Techniques for Biomimetic Drug Development, Formulation, and Polymorphic Characterization.利用X射线衍射技术进行仿生药物研发、制剂研究及多晶型表征。
Biomimetics (Basel). 2020 Dec 30;6(1):1. doi: 10.3390/biomimetics6010001.
3
Density Functional Theory in the Prediction of Mutagenicity: A Perspective.
密度泛函理论在预测致突变性方面的应用:一个视角。
Chem Res Toxicol. 2021 Feb 15;34(2):179-188. doi: 10.1021/acs.chemrestox.0c00113. Epub 2020 Aug 7.
4
Acid-responsive nanospheres from an asparagine-derived amphiphile.源自天冬酰胺衍生两亲分子的酸响应性纳米球。
RSC Adv. 2015;5:8585-8590. doi: 10.1039/C4RA11884G.
5
Development of a Control Strategy for Benzene Impurity in HPMCAS-Stabilized Spray-Dried Dispersion Drug Products Using a Science-Based and Risk-Based Approach.采用基于科学和风险的方法制定HPMCAS稳定的喷雾干燥分散体药物产品中苯杂质的控制策略。
Pharm Res. 2015 Aug;32(8):2636-48. doi: 10.1007/s11095-015-1649-7. Epub 2015 Feb 28.
6
Preparation, characterization and in vitro/vivo evaluation of tectorigenin solid dispersion with improved dissolution and bioavailability.具有改善溶出度和生物利用度的鸢尾黄素固体分散体的制备、表征及体内外评价
Eur J Drug Metab Pharmacokinet. 2016 Aug;41(4):413-22. doi: 10.1007/s13318-015-0265-6. Epub 2015 Feb 11.
7
In vitro characterization of a novel polymeric system for preparation of amorphous solid drug dispersions.制备无定形固体药物分散体的新型聚合物系统的体外特性研究。
AAPS J. 2014 Jul;16(4):685-97. doi: 10.1208/s12248-014-9590-y. Epub 2014 May 2.
8
In vitro and in vivo evaluation of amorphous solid dispersions generated by different bench-scale processes, using griseofulvin as a model compound.采用灰黄霉素作为模型化合物,通过不同的中试规模工艺生成无定形固体分散体的体外和体内评价。
AAPS J. 2013 Apr;15(2):608-17. doi: 10.1208/s12248-013-9469-3. Epub 2013 Mar 2.
9
Evaluation of drug load and polymer by using a 96-well plate vacuum dry system for amorphous solid dispersion drug delivery.采用 96 孔板真空干燥系统评价无定形固体分散体药物传递中的载药量和聚合物。
AAPS PharmSciTech. 2012 Jun;13(2):713-22. doi: 10.1208/s12249-012-9795-2. Epub 2012 May 5.
10
Application of dissolution/permeation system for evaluation of formulation effect on oral absorption of poorly water-soluble drugs in drug development.用于评价制剂对难溶性药物口服吸收影响的溶出/渗透系统在药物开发中的应用。
Pharm Res. 2012 Jun;29(6):1485-94. doi: 10.1007/s11095-011-0623-2. Epub 2011 Dec 2.