非病毒载体介导的siRNA肿瘤靶向递送：安全有效的癌症治疗方法
Tumor-targeted delivery of siRNA by non-viral vector: safe and effective cancer therapy.
作者信息
Chen Yunching, Huang Leaf
机构信息
University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Division of Molecular Pharmaceutics, Campus Box 7360 Kerr Hall, Chapel Hill, NC 27599, USA.
出版信息
Expert Opin Drug Deliv. 2008 Dec;5(12):1301-11. doi: 10.1517/17425240802568505.
Abstract
RNA interference technology has been developed as a potential therapeutic agent for many indications, including cancer. Silencing a specific oncogene in tumor cells brings about cell death both in vitro and in vivo. However, there is a great need for powerful delivery strategies to enhance the therapeutic effect of small interfering RNA (siRNA). This review summarizes different signaling pathways inhibited by siRNA and the advantages of targeted siRNA as a delivery system.
摘要
RNA干扰技术已被开发为一种针对包括癌症在内的多种适应症的潜在治疗药物。在肿瘤细胞中沉默特定的癌基因可在体外和体内导致细胞死亡。然而，迫切需要强大的递送策略来增强小干扰RNA（siRNA）的治疗效果。本综述总结了siRNA抑制的不同信号通路以及靶向siRNA作为递送系统的优势。
相似文献
1
Tumor-targeted delivery of siRNA by non-viral vector: safe and effective cancer therapy.
Expert Opin Drug Deliv. 2008 Dec;5(12):1301-11. doi: 10.1517/17425240802568505.
2
Functional nanostructures for effective delivery of small interfering RNA therapeutics.
Theranostics. 2014 Sep 19;4(12):1211-32. doi: 10.7150/thno.8491. eCollection 2014.
3
Strategies for in vivo siRNA delivery in cancer.
Mini Rev Med Chem. 2008 Mar;8(3):248-55. doi: 10.2174/138955708783744074.
4
Therapeutic targeting in the silent era: advances in non-viral siRNA delivery.
Mol Biosyst. 2010 Jul;6(7):1143-61. doi: 10.1039/c001050m. Epub 2010 Apr 29.
5
A review of the current status of siRNA nanomedicines in the treatment of cancer.
Biomaterials. 2013 Sep;34(27):6429-43. doi: 10.1016/j.biomaterials.2013.04.060. Epub 2013 May 30.
6
Small Interfering RNAs and their Delivery Systems: A Novel Powerful Tool for the Potential Treatment of HIV Infections.
Curr Mol Pharmacol. 2020;13(3):173-181. doi: 10.2174/1874467212666191023120954.
7
Advances in siRNA delivery in cancer therapy.
Artif Cells Nanomed Biotechnol. 2018 Mar;46(2):274-283. doi: 10.1080/21691401.2017.1307210. Epub 2017 Apr 19.
8
Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity.
Adv Drug Deliv Rev. 2007 Mar 30;59(2-3):164-82. doi: 10.1016/j.addr.2007.03.010. Epub 2007 Mar 21.
9
CXCR4-targeted modular peptide carriers for efficient anti-VEGF siRNA delivery.
Int J Pharm. 2016 Dec 30;515(1-2):431-440. doi: 10.1016/j.ijpharm.2016.10.049. Epub 2016 Oct 24.
10
Multifunctional nanocarrier based on clay nanotubes for efficient intracellular siRNA delivery and gene silencing.
J Biomater Appl. 2014 Apr;28(8):1180-9. doi: 10.1177/0885328213501215. Epub 2013 Aug 28.
引用本文的文献
1
Principle, application and challenges of development siRNA-based therapeutics against bacterial and viral infections: a comprehensive review.
Front Microbiol. 2024 Jun 13;15:1393646. doi: 10.3389/fmicb.2024.1393646. eCollection 2024.
2
Molecular Engineering of Functional SiRNA Agents.
ACS Synth Biol. 2024 Jun 21;13(6):1906-1915. doi: 10.1021/acssynbio.4c00181. Epub 2024 May 11.
3
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges.
J Biomed Sci. 2023 Oct 16;30(1):88. doi: 10.1186/s12929-023-00981-9.
4
Survivin Small Molecules Inhibitors: Recent Advances and Challenges.
Molecules. 2023 Feb 1;28(3):1376. doi: 10.3390/molecules28031376.
5
Insights on prospects of nano-siRNA based approaches in treatment of Cancer.
Front Pharmacol. 2022 Aug 25;13:985670. doi: 10.3389/fphar.2022.985670. eCollection 2022.
6
Small interfering RNA for cancer treatment: overcoming hurdles in delivery.
Acta Pharm Sin B. 2020 Nov;10(11):2075-2109. doi: 10.1016/j.apsb.2020.10.005. Epub 2020 Oct 13.
7
A review on current status of antiviral siRNA.
Rev Med Virol. 2018 Jul;28(4):e1976. doi: 10.1002/rmv.1976. Epub 2018 Apr 15.
8
Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells.
Front Pharmacol. 2017 Apr 4;8:182. doi: 10.3389/fphar.2017.00182. eCollection 2017.
9
PLGA-based dual targeted nanoparticles enhance miRNA transfection efficiency in hepatic carcinoma.
Sci Rep. 2017 Apr 7;7:46250. doi: 10.1038/srep46250.
10
Biological effects of RNAi targeted inhibiting Tiam1 gene expression on cholangiocarcinoma cells.
Int J Clin Exp Pathol. 2015 Dec 1;8(12):15511-26. eCollection 2015.
本文引用的文献
1
An efficient and low immunostimulatory nanoparticle formulation for systemic siRNA delivery to the tumor.
J Control Release. 2008 Oct 6;131(1):64-9. doi: 10.1016/j.jconrel.2008.07.006. Epub 2008 Jul 13.
2
Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts.
Eur J Pharm Biopharm. 2008 Nov;70(3):718-25. doi: 10.1016/j.ejpb.2008.06.026. Epub 2008 Jul 4.
3
Induction of apoptosis in murine neuroblastoma by systemic delivery of transferrin-shielded siRNA polyplexes for downregulation of Ran.
Oligonucleotides. 2008 Jun;18(2):161-74. doi: 10.1089/oli.2008.0112.
4
Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes.
J Control Release. 2008 Sep 24;130(3):266-74. doi: 10.1016/j.jconrel.2008.06.004. Epub 2008 Jun 12.
5
Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications.
Expert Opin Ther Targets. 2008 May;12(5):637-45. doi: 10.1517/14728222.12.5.637.
6
Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA.
Mol Ther. 2008 May;16(5):942-6. doi: 10.1038/mt.2008.51. Epub 2008 Mar 18.
7
Targeted delivery of small interfering RNA: approaching effective cancer therapies.
Cancer Res. 2008 Mar 1;68(5):1247-50. doi: 10.1158/0008-5472.CAN-07-5810.
8
Therapeutic nanoparticles for drug delivery in cancer.
Clin Cancer Res. 2008 Mar 1;14(5):1310-6. doi: 10.1158/1078-0432.CCR-07-1441.
9
Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth.
J Natl Cancer Inst. 2008 Mar 5;100(5):359-72. doi: 10.1093/jnci/djn024. Epub 2008 Feb 26.
10
Effect of blocking VEGF, hTERT and Bcl-xl by multiple shRNA expression vectors on the human laryngeal squamous carcinoma xenograft in nude mice.
Cancer Biol Ther. 2008 May;7(5):734-9. doi: 10.4161/cbt.7.5.5722. Epub 2008 May 12.
Zotero 插件