非病毒载体介导的siRNA肿瘤靶向递送：安全有效的癌症治疗方法
Tumor-targeted delivery of siRNA by non-viral vector: safe and effective cancer therapy.
作者信息
Chen Yunching, Huang Leaf
机构信息
University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Division of Molecular Pharmaceutics, Campus Box 7360 Kerr Hall, Chapel Hill, NC 27599, USA.
出版信息
Expert Opin Drug Deliv. 2008 Dec;5(12):1301-11. doi: 10.1517/17425240802568505.
Abstract
RNA interference technology has been developed as a potential therapeutic agent for many indications, including cancer. Silencing a specific oncogene in tumor cells brings about cell death both in vitro and in vivo. However, there is a great need for powerful delivery strategies to enhance the therapeutic effect of small interfering RNA (siRNA). This review summarizes different signaling pathways inhibited by siRNA and the advantages of targeted siRNA as a delivery system.
摘要
RNA干扰技术已被开发为一种针对包括癌症在内的多种适应症的潜在治疗药物。在肿瘤细胞中沉默特定的癌基因可在体外和体内导致细胞死亡。然而，迫切需要强大的递送策略来增强小干扰RNA（siRNA）的治疗效果。本综述总结了siRNA抑制的不同信号通路以及靶向siRNA作为递送系统的优势。
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