用于癌症治疗的小干扰RNA：克服递送障碍
Small interfering RNA for cancer treatment: overcoming hurdles in delivery.
作者信息
Charbe Nitin Bharat, Amnerkar Nikhil D, Ramesh B, Tambuwala Murtaza M, Bakshi Hamid A, Aljabali Alaa A A, Khadse Saurabh C, Satheeshkumar Rajendran, Satija Saurabh, Metha Meenu, Chellappan Dinesh Kumar, Shrivastava Garima, Gupta Gaurav, Negi Poonam, Dua Kamal, Zacconi Flavia C
机构信息
Departamento de Quimica Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile.
Sri Adichunchunagiri College of Pharmacy, Sri Adichunchunagiri University, BG Nagar, Karnataka 571418, India.
出版信息
Acta Pharm Sin B. 2020 Nov;10(11):2075-2109. doi: 10.1016/j.apsb.2020.10.005. Epub 2020 Oct 13.
In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.
在许多方面，癌细胞与健康细胞不同。许多基于纳米技术的战术性药物递送系统都是基于癌细胞与健康细胞之间的差异。目前，基于纳米技术的递送系统是将基于DNA的产品递送至癌细胞的最具前景的工具。本综述旨在突出脂质和聚合物纳米载体用于向癌细胞递送siRNA的最新进展。它还提供了有关siRNA发展及其作用机制的必要信息。总体而言，本综述让我们清楚地了解了基于脂质和聚合物的药物递送系统，这些系统未来可能成为将基础siRNA生物学转化为基于siRNA的癌症治疗方法的基础。
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