Sanguino Angela, Lopez-Berestein Gabriel, Sood Anil K
Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mini Rev Med Chem. 2008 Mar;8(3):248-55. doi: 10.2174/138955708783744074.
A better understanding of the mechanisms involved in small interference RNA (siRNA) gene silencing opens new horizons for the development of the targeted therapy of malignant and benign diseases. As a research tool, siRNA has proven to be highly effective in silencing specific genes and modulating intracellular signaling pathways. However, systemic delivery of siRNA has been more problematic due to degradation and poor cellular uptake. In order to overcome these limitations, a variety of strategies are being developed including new delivery vehicles and chemical modifications. Here, we review potential approaches for the systemic delivery of siRNA for cancer treatment.
对小干扰RNA（siRNA）基因沉默所涉及机制的更好理解为恶性和良性疾病的靶向治疗开辟了新视野。作为一种研究工具，siRNA已被证明在沉默特定基因和调节细胞内信号通路方面非常有效。然而，由于降解和细胞摄取不良，siRNA的全身递送一直存在更多问题。为了克服这些限制，正在开发各种策略，包括新的递送载体和化学修饰。在这里，我们综述了用于癌症治疗的siRNA全身递送的潜在方法。
