Chang Zhi-Yang, Chiang Chiao-Hsi, Lu Da-Wen, Yeh Ming-Kung
Tri-Service General Hospital, National Defense Medical Center, Graduate Institute of Life Sciences, School of Pharmacy, Neihu, Taipei 114, Taiwan.
Expert Opin Drug Deliv. 2008 Dec;5(12):1313-21. doi: 10.1517/17425240802544159.
Erythropoietin (EPO), a glycoprotein, plays an important role in erythropoiesis and neuroprotection. EPO therapies for anemia or neurodegenerative diseases require frequent injections or high-dose systemic administration which may cause unwanted side effects. Various strategies for EPO delivery have been investigated for increasing EPO bioavailability and decreasing side effects, including nano/micro particles, PEGylation of EPO and transport-mediated delivery systems. Nano/micro particles provide EPO with long-term effect and protect EPO against proteolytic cleavage. PEGylated EPO prolong circulating time and reduce injection frequency of anemia treatment. A transport-mediated delivery system enables protein to cross biological barriers. Presently, there is no report about an effective delivery system of EPO for neuroprotection. This review focuses on EPO delivery systems for erythropoiesis or neuroprotection with prolonged duration and enhanced bioavailability.
促红细胞生成素（EPO）是一种糖蛋白，在红细胞生成和神经保护中发挥重要作用。用于治疗贫血或神经退行性疾病的EPO疗法需要频繁注射或高剂量全身给药，这可能会引起不良副作用。为了提高EPO的生物利用度并减少副作用，人们研究了各种EPO递送策略，包括纳米/微粒、EPO的聚乙二醇化以及转运介导的递送系统。纳米/微粒可为EPO提供长效作用，并保护EPO免受蛋白水解切割。聚乙二醇化EPO可延长循环时间并减少贫血治疗的注射频率。转运介导的递送系统可使蛋白质穿过生物屏障。目前，尚无关于用于神经保护的有效EPO递送系统的报道。本综述重点关注用于红细胞生成或神经保护的具有延长作用时间和增强生物利用度的EPO递送系统。
