Shahriari Ali, Eng Michael, Tranquilli Maryann, Elefteriades John A
Section of Cardiac Surgery, Yale University School of Medicine, 333 Cedar St., New Haven, CT 05610, USA.
J Card Surg. 2009 Jul-Aug;24(4):392-6. doi: 10.1111/j.1540-8191.2008.00762.x.
Aortic root replacement (ARR) has been recognized as the standard therapy for diseases of the aortic root since its introduction into clinical practice. ARR currently provides excellent long-term benefit with acceptable perioperative risk and excellent long-term morbidity and mortality. During ARR, coronary button misalignment may produce myocardial ischemia, ventricular arrhythmias, and pump failure leading to death if unrecognized. Here we review our experience with coronary insufficiency after ARR.
Between January 1995 and March 2006, 139 consecutive patients underwent ARR at Yale-New Haven Hospital. A retrospective review of their medical records was conducted. The mean age of the patients was 54.5 years. Aortic root aneurysm was the indication for surgery in 123 patients, acute type A dissection in 14, and endocarditis in two.
All patients underwent a modified Bentall operation with a mechanical (87%) or biological (13%) valve prosthesis and coronary artery button reimplantation. The overall 30-day mortality was 4.3% (six patients). Three patients (2.2%) underwent rescue coronary artery bypass grafting (CABG) to the left, right, or both coronary arterial systems for ischemia due to presumed coronary button misalignment. These patients presented with ventricular arrhythmias or hemodynamic compromise. All three showed excellent response to rescue CABG and remain alive and well in late follow-up.
Coronary insufficiency after reconstruction of the aortic root is an uncommon but acutely life-threatening occurrence. This lethal condition may present with difficulty in weaning from cardiopulmonary bypass; echocardiographic signs of major wall motion abnormalities; and electrocardiographic evidence of ischemia, pump failure, and ventricular arrhythmias. Rescue CABG in this situation is life-saving. Immediate rescue CABG should be performed if coronary ischemia is suspected after composite graft replacement of the aortic root.
自主动脉根部置换术(ARR)应用于临床实践以来,它已被公认为治疗主动脉根部疾病的标准疗法。目前,ARR能带来良好的长期效益,围手术期风险可接受,长期发病率和死亡率也较低。在ARR过程中,若未识别出冠状动脉纽扣错位,可能会导致心肌缺血、室性心律失常和泵衰竭,进而导致死亡。在此,我们回顾了我们在ARR后冠状动脉供血不足方面的经验。
1995年1月至2006年3月期间,139例连续患者在耶鲁-纽黑文医院接受了ARR。对他们的病历进行了回顾性分析。患者的平均年龄为54.5岁。123例患者因主动脉根部瘤接受手术,14例因急性A型主动脉夹层,2例因心内膜炎。
所有患者均接受了改良Bentall手术,使用机械瓣膜(87%)或生物瓣膜(13%)假体,并进行冠状动脉纽扣再植入。30天总死亡率为4.3%(6例患者)。3例患者(2.2%)因推测的冠状动脉纽扣错位导致缺血,接受了左、右或双侧冠状动脉系统的挽救性冠状动脉旁路移植术(CABG)。这些患者出现了室性心律失常或血流动力学不稳定。所有3例患者对挽救性CABG反应良好,在后期随访中仍存活且状况良好。
主动脉根部重建术后的冠状动脉供血不足虽不常见,但会急性危及生命。这种致命情况可能表现为脱离体外循环困难;主要壁运动异常的超声心动图征象;以及缺血、泵衰竭和室性心律失常的心电图证据。在这种情况下,挽救性CABG可挽救生命。如果在主动脉根部复合移植物置换术后怀疑有冠状动脉缺血,应立即进行挽救性CABG。