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比较新生儿期诊断的先天性巨结肠症一期手术修复和分期手术修复的成本及并发症。

Comparing cost and complications of primary and staged surgical repair of neonatally diagnosed Hirschsprung's disease.

作者信息

Shinall Myrick C, Koehler Elizabeth, Shyr Yu, Lovvorn Harold N

机构信息

Department of Pediatric Surgery,Vanderbilt University School of Medicine, Nashville, TN 37232-9780, USA.

出版信息

J Pediatr Surg. 2008 Dec;43(12):2220-5. doi: 10.1016/j.jpedsurg.2008.08.048.

Abstract

BACKGROUND/PURPOSE: We questioned whether primary surgical correction of neonatally diagnosed Hirschsprung's Disease (HD) incurs higher costs or increased incidence of adverse events (AE) when compared with staged repair.

METHODS

We reviewed the medical records of all neonates diagnosed with HD at our institution between 1997 and 2007. Sixty subjects fulfilled criteria for inclusion. Twenty-seven neonates had primary repair, and 33 had staged repair. We measured inflation-adjusted total costs, direct costs, and total charges and 6 AE between the 2 groups. A generalized linear model was used to examine differences between group variables.

RESULTS

We found no statistically significant difference in costs or AE between primary and staged repair. Inflation-adjusted median financial data for primary or staged repair were, respectively, as follows: total costs, $35,670 vs $38,538 (P = .617); direct costs, $18,453 vs $23,937 (P = .128); total charges, $107,315 vs $102,492 (P = .690). Adverse events occurred in 48% of primary repair subjects and 36% of staged repair subjects (P = .434); no single AE differed significantly between the two groups.

CONCLUSIONS

We found no statistical evidence that primary neonatal correction of HD adds cost or risk of AE when compared with a traditional staged approach in neonates who met inclusion criteria.

摘要

背景/目的:我们探讨了与分期修复相比,对新生儿期诊断的先天性巨结肠症(HD)进行一期手术矫正是否会产生更高的成本或增加不良事件(AE)的发生率。

方法

我们回顾了1997年至2007年间在本机构诊断为HD的所有新生儿的病历。60名受试者符合纳入标准。27名新生儿进行了一期修复,33名进行了分期修复。我们测量了两组之间经通胀调整后的总成本、直接成本、总费用以及6种不良事件。使用广义线性模型来检验组间变量的差异。

结果

我们发现一期修复和分期修复在成本或不良事件方面没有统计学上的显著差异。一期修复或分期修复经通胀调整后的中位财务数据分别如下:总成本,35,670美元对38,538美元(P = 0.617);直接成本,18,453美元对23,937美元(P = 0.128);总费用,107,315美元对102,492美元(P = 0.690)。48%的一期修复受试者和36%的分期修复受试者发生了不良事件(P = 0.434);两组之间没有单一不良事件存在显著差异。

结论

我们没有发现统计学证据表明,与传统分期方法相比,对符合纳入标准的新生儿进行先天性巨结肠症一期矫正会增加成本或不良事件风险。

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