• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

比较新生儿期诊断的先天性巨结肠症一期手术修复和分期手术修复的成本及并发症。

Comparing cost and complications of primary and staged surgical repair of neonatally diagnosed Hirschsprung's disease.

作者信息

Shinall Myrick C, Koehler Elizabeth, Shyr Yu, Lovvorn Harold N

机构信息

Department of Pediatric Surgery,Vanderbilt University School of Medicine, Nashville, TN 37232-9780, USA.

出版信息

J Pediatr Surg. 2008 Dec;43(12):2220-5. doi: 10.1016/j.jpedsurg.2008.08.048.

DOI:10.1016/j.jpedsurg.2008.08.048
PMID:19040939
Abstract

BACKGROUND/PURPOSE: We questioned whether primary surgical correction of neonatally diagnosed Hirschsprung's Disease (HD) incurs higher costs or increased incidence of adverse events (AE) when compared with staged repair.

METHODS

We reviewed the medical records of all neonates diagnosed with HD at our institution between 1997 and 2007. Sixty subjects fulfilled criteria for inclusion. Twenty-seven neonates had primary repair, and 33 had staged repair. We measured inflation-adjusted total costs, direct costs, and total charges and 6 AE between the 2 groups. A generalized linear model was used to examine differences between group variables.

RESULTS

We found no statistically significant difference in costs or AE between primary and staged repair. Inflation-adjusted median financial data for primary or staged repair were, respectively, as follows: total costs, $35,670 vs $38,538 (P = .617); direct costs, $18,453 vs $23,937 (P = .128); total charges, $107,315 vs $102,492 (P = .690). Adverse events occurred in 48% of primary repair subjects and 36% of staged repair subjects (P = .434); no single AE differed significantly between the two groups.

CONCLUSIONS

We found no statistical evidence that primary neonatal correction of HD adds cost or risk of AE when compared with a traditional staged approach in neonates who met inclusion criteria.

摘要

背景/目的:我们探讨了与分期修复相比,对新生儿期诊断的先天性巨结肠症(HD)进行一期手术矫正是否会产生更高的成本或增加不良事件(AE)的发生率。

方法

我们回顾了1997年至2007年间在本机构诊断为HD的所有新生儿的病历。60名受试者符合纳入标准。27名新生儿进行了一期修复,33名进行了分期修复。我们测量了两组之间经通胀调整后的总成本、直接成本、总费用以及6种不良事件。使用广义线性模型来检验组间变量的差异。

结果

我们发现一期修复和分期修复在成本或不良事件方面没有统计学上的显著差异。一期修复或分期修复经通胀调整后的中位财务数据分别如下:总成本,35,670美元对38,538美元(P = 0.617);直接成本,18,453美元对23,937美元(P = 0.128);总费用,107,315美元对102,492美元(P = 0.690)。48%的一期修复受试者和36%的分期修复受试者发生了不良事件(P = 0.434);两组之间没有单一不良事件存在显著差异。

结论

我们没有发现统计学证据表明,与传统分期方法相比,对符合纳入标准的新生儿进行先天性巨结肠症一期矫正会增加成本或不良事件风险。

相似文献

1
Comparing cost and complications of primary and staged surgical repair of neonatally diagnosed Hirschsprung's disease.比较新生儿期诊断的先天性巨结肠症一期手术修复和分期手术修复的成本及并发症。
J Pediatr Surg. 2008 Dec;43(12):2220-5. doi: 10.1016/j.jpedsurg.2008.08.048.
2
Lengths of stay and costs associated with children's hospitals.儿童医院的住院时长及相关费用。
Pediatrics. 2005 Apr;115(4):839-44. doi: 10.1542/peds.2004-1622.
3
Economic impact of failed or delayed primary repair of bladder exstrophy: differences in cost of hospitalization.膀胱外翻一期修复失败或延迟的经济影响:住院费用差异
J Urol. 2008 Feb;179(2):680-3. doi: 10.1016/j.juro.2007.09.093. Epub 2007 Dec 20.
4
Neonatal Soave endorectal pull-through for Hirschsprung's disease.新生儿Soave经肛门拖出术治疗先天性巨结肠症。
S Afr J Surg. 1999 May;37(2):47-9; discussion 49-50.
5
Cost-minimisation analysis of laparoscopic and open appendicectomy.腹腔镜阑尾切除术与开腹阑尾切除术的成本最小化分析
Eur J Surg. 1999 Jun;165(6):579-82. doi: 10.1080/110241599750006497.
6
Laryngeal cancer cost analysis: association of case-mix and treatment characteristics with medical charges.喉癌成本分析:病例组合及治疗特征与医疗费用的关联
Laryngoscope. 2000 Jan;110(1):1-7. doi: 10.1097/00005537-200001000-00001.
7
[Congenital megacolon in neonates and infants: impact of early, one-stage repair on morbidity and surgical complications].[新生儿及婴儿先天性巨结肠:早期一期修复对发病率及手术并发症的影响]
Pediatr Med Chir. 2004 Jul-Aug;26(4):241-4.
8
Primary pull-through with modified Duhamel technique: 1 institution's experience.采用改良杜哈梅尔技术的一期拖出术:一家机构的经验
J Pediatr Surg. 2007 Jun;42(6):1075-80. doi: 10.1016/j.jpedsurg.2007.01.061.
9
[Evaluation of direct hospital and extra-hospital cost of operative hysteroscopy and vaginal hysterectomy].
J Gynecol Obstet Biol Reprod (Paris). 1999 Jul;28(4):335-42.
10
Transanal endorectal pull-through in children with Hirschsprung's disease--technical refinements and comparison of results with the Duhamel procedure.先天性巨结肠患儿经肛门直肠内拖出术——技术改进及与杜哈梅尔手术结果的比较
J Pediatr Surg. 2009 Apr;44(4):767-72. doi: 10.1016/j.jpedsurg.2008.08.002.

引用本文的文献

1
Virus-Triggered Autoimmunity Was Associated With Hirschsprung's Disease Through Activation of Innate Immunity.病毒触发的自身免疫与先天性免疫的激活有关,与先天性巨结肠病有关。
J Immunol Res. 2024 Oct 26;2024:4838514. doi: 10.1155/2024/4838514. eCollection 2024.
2
The incidence of different forms of ileus following surgery for abdominal birth defects in infants: a systematic review with a meta-analysis method.婴儿腹部先天性缺陷手术后不同类型肠梗阻的发生率:一项采用荟萃分析方法的系统评价
Innov Surg Sci. 2021 Aug 17;6(4):127-150. doi: 10.1515/iss-2020-0042. eCollection 2021 Dec 1.
3
Hirschsprung disease - integrating basic science and clinical medicine to improve outcomes.
先天性巨结肠症——整合基础科学和临床医学以改善治疗效果。
Nat Rev Gastroenterol Hepatol. 2018 Mar;15(3):152-167. doi: 10.1038/nrgastro.2017.149. Epub 2018 Jan 4.
4
MicroRNA-939 inhibits cell proliferation via targeting LRSAM1 in Hirschsprung's disease.微小RNA-939通过靶向先天性巨结肠中的LRSAM1抑制细胞增殖。
Aging (Albany NY). 2017 Dec 18;9(12):2471-2479. doi: 10.18632/aging.101331.
5
Downregulated Expression of Long Non-Coding RNA LOC101926975 Impairs both Cell Proliferation and Cell Cycle and Its Clinical Implication in Hirschsprung Disease Patients.长链非编码RNA LOC101926975的表达下调损害细胞增殖和细胞周期及其在先天性巨结肠症患者中的临床意义
Int J Med Sci. 2016 Apr 8;13(4):292-7. doi: 10.7150/ijms.14187. eCollection 2016.
6
Familial Hirschsprung's disease: a systematic review.家族性先天性巨结肠病:一项系统综述。
Pediatr Surg Int. 2015 Aug;31(8):695-700. doi: 10.1007/s00383-015-3730-z. Epub 2015 Jul 16.
7
Skin-derived precursors generate enteric-type neurons in aganglionic jejunum.皮肤来源的前体细胞在无神经节空肠中产生肠型神经元。
J Pediatr Surg. 2014 Dec;49(12):1809-14. doi: 10.1016/j.jpedsurg.2014.09.023. Epub 2014 Oct 1.
8
Estimating incremental costs with skew: a cautionary note.用偏度估计增量成本:一个警示。
Appl Health Econ Health Policy. 2012 Sep 1;10(5):319-29. doi: 10.2165/11632430-000000000-00000.