Scaramelli Alejandro, Braga Patricia, Avellanal Andrea, Bogacz Alicia, Camejo Claudia, Rega Isabel, Messano Tamara, Arciere Beatriz
Instituto de Neurología, Hospital de Clínicas, Av. Italia S/N, Montevideo 11600, Uruguay.
Seizure. 2009 May;18(4):246-50. doi: 10.1016/j.seizure.2008.10.007. Epub 2008 Nov 29.
Although recent advances in seizure anticipation have been achieved with the development of several biomathematical electroencephalographic (EEG) methods, pre-ictal clinical phenomena have not been extensively investigated. The aim of the study was to thoroughly analyze premonitory or prodromal symptoms (PS) in a randomly selected sample of 100 adult epileptic patients. A semi-structured protocol was used for in-person interviews to both patients and observers. PS were found in 39% of patients, the most frequent ones being behavioral, cognitive and mood changes. Both patients with focal and generalized epilepsies reported prodromes, although they were more frequently found in the former group. PS were mostly perceived preceding complex partial and generalized tonic-clonic seizures. Prodromal symptoms were reported to have an insidious onset and their duration ranged from 30min to several hours. The potential value of prodromes in seizure anticipation would allow the use of preventive and therapeutic measures, including drugs, neurostimulation procedures and behavioral intervention.
尽管随着几种生物数学脑电图（EEG）方法的发展，在癫痫发作预测方面取得了最新进展，但发作前的临床现象尚未得到广泛研究。本研究的目的是对100名成年癫痫患者的随机样本进行全面分析，以了解先兆或前驱症状（PS）。采用半结构化方案对患者和观察者进行面对面访谈。39%的患者发现有PS，最常见的是行为、认知和情绪变化。局灶性癫痫和全身性癫痫患者均报告有前驱症状，尽管前者组中更常见。PS大多出现在复杂部分性发作和全身性强直阵挛发作之前。据报告，前驱症状起病隐匿，持续时间从30分钟到数小时不等。前驱症状在癫痫发作预测中的潜在价值将允许采取预防和治疗措施，包括药物、神经刺激程序和行为干预。
