1例经自体造血干细胞移植治疗的POEMS综合征病例。
A case of POEMS syndrome treated by autologous hematopoietic stem-cell transplantation.
作者信息
Créange Alain, Chater Ahmed, Brouet Jean-Claude, Jaccard Arnaud, Rahmouni Alain, Lefaucheur Jean-Pascal, Santin Aline
机构信息
Service de Neurologie, Hôpital Henri-Mondor, Créteil Cedex, France.
出版信息
Nat Clin Pract Neurol. 2008 Dec;4(12):686-91. doi: 10.1038/ncpneuro0942.
BACKGROUND
A 55-year-old woman with no remarkable medical history presented to a neurology ward with a 17-week history of rapidly progressive gait difficulties that confined her to a wheelchair.
INVESTIGATIONS
Electroneuromyography, immunoelectrophoresis, bone radiography, lesion-targeted bone-marrow examination, blood tests.
DIAGNOSIS
Neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome.
MANAGEMENT
High-dose chemotherapy and autologous hematopoietic stem-cell transplantation.
背景
一名55岁女性，既往无显著病史，因快速进展的步态困难17周，已需依靠轮椅行动，入住神经内科病房。
检查
神经电生理检查、免疫电泳、骨骼X线检查、病灶靶向骨髓检查、血液检查。
诊断
多发性神经病变、器官肿大、内分泌病变、单克隆丙种球蛋白病及皮肤改变（POEMS）综合征。
治疗
大剂量化疗及自体造血干细胞移植。
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