免疫介导性神经病变的发病机制与治疗。
Pathogenesis and treatment of immune-mediated neuropathies.
机构信息
Department of Neurology, Johns Hopkins Hospital, Baltimore, USA.
出版信息
Ther Adv Neurol Disord. 2009 Jul;2(4):261-81. doi: 10.1177/1756285609104792.
Abstract
Immune-mediated neuropathies represent a heterogeneous spectrum of peripheral nerve disorders that can be classified according to time course, predominant involvement of motor/sensory fibers, distribution of deficits and paraclinical parameters such as electrophysiology and serum antibodies. In the last few years, significant advances have been achieved in elucidating underlying pathomechanisms, which made it possible to identify potential therapeutic targets. In this review, we discuss the latest development in pathogenesis and treatment of immune-mediated neuropathies.
摘要
免疫介导性神经病是一组异质性的周围神经病，可根据发病时间、运动/感觉纤维受累为主、缺损分布和电生理学及血清抗体等临床参数进行分类。在过去的几年中，阐明潜在发病机制方面取得了重大进展，这使得确定潜在的治疗靶点成为可能。在这篇综述中，我们讨论了免疫介导性神经病发病机制和治疗的最新进展。
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