Ham H R, Piepsz A
Department of Nuclear Medicine, Saint Pierre Hospital, Brussels, Belgium.
J Nucl Med. 1991 Jun;32(6):1294-7.
This work was undertaken to look for distribution volume-plasma clearance converting equations(s) that can be used to estimate glomerular filtration rate (GFR) in children. GFR calculated using the two-blood sample slope-intercept method was used for comparison. It was shown that the 2-hr distribution volume and the two-blood sample clearance were closely related. For all the age groups, the coefficient of correlation between these two parameters was high (range: 0.95 to 0.99) and the s.e.e. was low (range 0.76-3.86 ml/min). It was also shown that a linear equation (GFR = 2,602 V120-0,273) could be used to convert the two hour distribution volume into an accurate estimate of two-blood sample GFR whatever the age of the patient. The use of the single-sample technique for measuring GFR in children is therefore recommendable.
开展这项工作是为了寻找可用于估算儿童肾小球滤过率（GFR）的分布容积 - 血浆清除率转换方程。使用双血样斜率截距法计算的GFR用于比较。结果表明，2小时分布容积与双血样清除率密切相关。对于所有年龄组，这两个参数之间的相关系数很高（范围：0.95至0.99），标准误差很低（范围0.76 - 3.86 ml/min）。还表明，无论患者年龄如何，线性方程（GFR = 2,602 V120 - 0,273）可用于将两小时分布容积转换为双血样GFR的准确估计值。因此，建议使用单样本技术测量儿童的GFR。
