Mazière J C, Morlière P, Santus R
Laboratoire de Physico-Chimie de l'Adaptation Biologique, INSERM U312, Muséum National d'Histoire Naturelle, Paris, France.
J Photochem Photobiol B. 1991 Mar;8(4):351-60. doi: 10.1016/1011-1344(91)80111-t.
Lipoproteins are now recognized as major blood carriers of many hydrophobic porphyrins and related chromophores which are being investigated as possible photosensitizers in the photodynamic therapy of tumours. In vitro and in vivo studies have demonstrated the role of the low density lipoprotein (LDL) receptor pathway in the delivery of photosensitizers to tumour cells and its importance in porphyrin accumulation by tumours. Lysosomes, which are involved in the cellular processing of LDL, are important intracellular targets in the LDL-porphyrin-induced phototoxicity. The use of the LDL receptor pathway as a tool for enhancing the selectivity of photosensitizer delivery to tumour cells appears to be a promising field of research in the photodynamic therapy of tumours.
脂蛋白现在被认为是许多疏水性卟啉及相关发色团的主要血液载体，这些物质正作为肿瘤光动力疗法中可能的光敏剂进行研究。体外和体内研究已经证明了低密度脂蛋白（LDL）受体途径在将光敏剂递送至肿瘤细胞中的作用及其在肿瘤卟啉积累中的重要性。参与LDL细胞处理的溶酶体是LDL-卟啉诱导的光毒性中的重要细胞内靶点。利用LDL受体途径作为增强光敏剂向肿瘤细胞递送选择性的工具，似乎是肿瘤光动力疗法中一个有前景的研究领域。
