非共价键连接的 PDT 药物-金纳米颗粒缀合物使 PDT 药物深入肿瘤内部。
Deep penetration of a PDT drug into tumors by noncovalent drug-gold nanoparticle conjugates.
机构信息
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.
出版信息
J Am Chem Soc. 2011 Mar 2;133(8):2583-91. doi: 10.1021/ja108846h. Epub 2011 Feb 4.
Abstract
Efficient drug delivery to tumors is of ever-increasing importance. Single-visit diagnosis and treatment sessions are the goal of future theranostics. In this work, a noncovalent PDT cancer drug-gold nanoparticle (Au NP) conjugate system performed a rapid drug release and deep penetration of the drug into tumors within hours. The drug delivery mechanism of the PDT drug through Au NPs into tumors by passive accumulation was investigated via fluorescence imaging, elemental analysis, and histological staining. The pharmacokinetics of the conjugates over a 7-day test period showed rapid drug excretion, as monitored via the fluorescence of the drug in urine. Moreover, the biodistribution of Au NPs in this study period indicated clearance of the NPs from the mice. This study suggests that noncovalent delivery via Au NPs provides an attractive approach for cancer drugs to penetrate deep into the center of tumors.
摘要
高效的药物递送至肿瘤具有越来越重要的意义。单次就诊的诊断和治疗是未来治疗学的目标。在这项工作中，非共价 PDT 癌症药物-金纳米颗粒（Au NP）缀合物系统在数小时内实现了药物的快速释放和深入肿瘤渗透。通过荧光成像、元素分析和组织学染色研究了 PDT 药物通过 Au NPs 被动积累进入肿瘤的药物递药机制。通过尿液中药物的荧光监测，在 7 天的测试期间，研究了缀合物的药代动力学，结果表明药物快速排泄。此外，在本研究期间，Au NPs 的生物分布表明 NPs 从小鼠体内清除。本研究表明，通过 Au NPs 的非共价递药为癌症药物深入肿瘤中心提供了一种有吸引力的方法。
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