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本文引用的文献

1
Trazodone enhances sleep in subjective quality but not in objective duration.曲唑酮可改善睡眠的主观质量，但对客观睡眠时间并无影响。
Br J Clin Pharmacol. 1983 Aug;16(2):139-44. doi: 10.1111/j.1365-2125.1983.tb04977.x.
2
Effects of ritanserin on sleep disturbances of dysthymic patients.利坦色林对心境恶劣障碍患者睡眠障碍的影响。
Psychopharmacology (Berl). 1988;96(3):395-9. doi: 10.1007/BF00216069.
3
The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to L-tryptophan.慢性利坦色林治疗对睡眠及L-色氨酸神经内分泌反应的影响。
Psychopharmacology (Berl). 1987;93(4):416-20. doi: 10.1007/BF00207228.
4
5-Hydroxytryptamine-2 antagonist increases human slow wave sleep.
Brain Res. 1986 Jul 16;378(1):164-8. doi: 10.1016/0006-8993(86)90299-4.
5
Effects of repeated ritanserin on middle-aged poor sleepers.
Psychopharmacology (Berl). 1989;99(2):219-21. doi: 10.1007/BF00442811.
6
Suppression of sleep-related prolactin secretion and enhancement of sleep-related growth hormone secretion.抑制与睡眠相关的催乳素分泌并增强与睡眠相关的生长激素分泌。
J Clin Invest. 1975 Sep;56(3):690-7. doi: 10.1172/JCI108139.

一项关于利坦色林对人类慢波睡眠影响的剂量反应研究。

A dose-response study examining the effects of ritanserin on human slow wave sleep.

作者信息

Idzikowski C, Mills F J, James R J

机构信息

Clinical Pharmacology Unit, Janssen Research Foundation, Wantage, Oxon.

出版信息

Br J Clin Pharmacol. 1991 Feb;31(2):193-6. doi: 10.1111/j.1365-2125.1991.tb05514.x.

DOI:10.1111/j.1365-2125.1991.tb05514.x
PMID:1904750
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1368392/
Abstract

This study investigated the effects of placebo, 1 mg, 3 mg, 10 mg and 30 mg ritanserin and 10 mg diazepam on human sleep. Twelve normal volunteers participated in this randomized, double-blind, placebo-controlled cross-over sleep study. A clear dose-response relationship was found for ritanserin with higher doses evoking increased duration of slow wave sleep.

摘要

本研究调查了安慰剂、1毫克、3毫克、10毫克和30毫克利坦色林以及10毫克地西泮对人类睡眠的影响。12名正常志愿者参与了这项随机、双盲、安慰剂对照的交叉睡眠研究。发现利坦色林存在明确的剂量反应关系，剂量越高，慢波睡眠持续时间越长。