Borbély A A, Trachsel L, Tobler I
Institute of Pharmacology, University of Zürich, Switzerland.
Eur J Pharmacol. 1988 Nov 1;156(2):275-8. doi: 10.1016/0014-2999(88)90332-9.
Ritanserin (1.0 and 2.5 mg/kg i.p.) was administered to rats before the start, of the light period, and sleep was recorded during the subsequent 12 h. The higher dose reduced sleep in the first 3 h. Both doses caused a more prolonged suppression of REM sleep. Spectral analysis of the EEG in non-REM sleep showed an increase of power density in the low frequency range (1.5-6 Hz) and a depression in the high frequency range (8-25 Hz). Since these changes differ from those previously observed after sleep deprivation, it is premature to conclude that the drug induces a physiological sleep intensification.
在光照期开始前，给大鼠腹腔注射利坦色林（1.0和2.5毫克/千克），并在随后的12小时内记录睡眠情况。较高剂量在最初3小时内减少了睡眠。两种剂量均导致快速眼动睡眠的抑制时间延长。非快速眼动睡眠期脑电图的频谱分析显示，低频范围（1.5 - 6赫兹）的功率密度增加，高频范围（8 - 25赫兹）的功率密度降低。由于这些变化与先前睡眠剥夺后观察到的变化不同，因此现在得出该药物诱导生理性睡眠增强的结论还为时过早。
