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1
Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303).吉西他滨联合贝伐珠单抗对比吉西他滨联合安慰剂治疗晚期胰腺癌患者：癌症和白血病 B 组（CALGB 80303）的 III 期试验。
J Clin Oncol. 2010 Aug 1;28(22):3617-22. doi: 10.1200/JCO.2010.28.1386. Epub 2010 Jul 6.
2
A mouse to human search for plasma proteome changes associated with pancreatic tumor development.从鼠到人的探索：寻找与胰腺肿瘤发生相关的血浆蛋白质组变化
PLoS Med. 2008 Jun 10;5(6):e123. doi: 10.1371/journal.pmed.0050123.
3
Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma.在髓母细胞瘤和胶质瘤的临床相关小鼠模型中，新鲜手术标本的直接原位移植可保留CD133 +肿瘤细胞。
Stem Cells. 2008 Jun;26(6):1414-24. doi: 10.1634/stemcells.2007-1009. Epub 2008 Apr 10.
4
Modeling therapy resistance in genetically engineered mouse cancer models.在基因工程小鼠癌症模型中模拟治疗抗性
Drug Resist Updat. 2008 Feb-Apr;11(1-2):51-60. doi: 10.1016/j.drup.2007.11.002. Epub 2007 Dec 31.
5
Maximizing mouse cancer models.优化小鼠癌症模型。
Nat Rev Cancer. 2007 Sep;7(9):645-58. doi: 10.1038/nrc2192.
6
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.在遗传性乳腺癌条件性小鼠模型中对乳腺肿瘤进行化疗耐药的选择性诱导。
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12117-22. doi: 10.1073/pnas.0702955104. Epub 2007 Jul 11.
7
An in vivo platform for translational drug development in pancreatic cancer.一种用于胰腺癌转化药物开发的体内平台。
Clin Cancer Res. 2006 Aug 1;12(15):4652-61. doi: 10.1158/1078-0432.CCR-06-0113.
8
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.人类表皮生长因子受体（EGFR）激酶结构域突变对肺肿瘤发生及体内对EGFR靶向治疗敏感性的影响。
Cancer Cell. 2006 Jun;9(6):485-95. doi: 10.1016/j.ccr.2006.04.022. Epub 2006 May 25.
9
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.在人类肺癌中发现的突变表皮生长因子受体在小鼠体内诱发的肺腺癌对酪氨酸激酶抑制剂或受体下调有反应。
Genes Dev. 2006 Jun 1;20(11):1496-510. doi: 10.1101/gad.1417406. Epub 2006 May 16.
10
Paradoxical roles of the immune system during cancer development.免疫系统在癌症发展过程中的矛盾作用。
Nat Rev Cancer. 2006 Jan;6(1):24-37. doi: 10.1038/nrc1782.

The use of GEM models for experimental cancer therapeutics.

作者信息

Gopinathan Aarthi, Tuveson David A

出版信息

Dis Model Mech. 2008 Sep-Oct;1(2-3):83-6. doi: 10.1242/dmm.000570.

DOI:10.1242/dmm.000570
PMID:19048065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2562176/
Abstract
摘要