Tetsutani Kohhei, Ishiwata Kenji, Torii Motomi, Hamano Shinjiro, Hisaeda Hajime, Himeno Kunisuke
Department of Parasitology, Kyushu University Graduate School of Medicine, Fukuoka, Japan.
Am J Trop Med Hyg. 2008 Dec;79(6):819-22.
We investigated whether concurrent infection with Heligmosomoides polygyrus, an intestinal nematode, modulated anti-malaria parasite immunity and development of experimental cerebral malaria (ECM) in mice. The C57BL/6 mice infected with Plasmodium berghei ANKA showed typical symptoms of ECM. Interestingly, preceding H. polygyrus infection did not alter ECM development, despite accelerated P. berghei growth in vivo. Our observation provides a new insight that ECM can be induced in a fashion independent of the immune responses affected by concurrent H. polygyrus. Differentiation between protective immunity and infection-associated host-damaging inflammatory response is urgently required for understanding the pathogenesis of cerebral malaria.
我们研究了肠道线虫多枝单睾线虫的同时感染是否会调节小鼠体内抗疟原虫免疫及实验性脑型疟疾（ECM）的发展。感染伯氏疟原虫ANKA的C57BL/6小鼠表现出ECM的典型症状。有趣的是，尽管伯氏疟原虫在体内生长加速，但先前的多枝单睾线虫感染并未改变ECM的发展。我们的观察提供了一个新的见解，即ECM可以以一种独立于多枝单睾线虫同时感染所影响的免疫反应的方式被诱导。为了解脑型疟疾的发病机制，迫切需要区分保护性免疫和感染相关的宿主损伤性炎症反应。
