Sagach V F, Zhukova A V
Fiziol Zh (1978). 1991 Mar-Apr;37(2):25-31.
Experiments on anaesthetized dogs have shown, that reperfusion of ischemized tissues is accompanied by significant increase in thromboxane A2 (Tx A2) and prostacyclin (PG I2) blood level and by development of pronounced cardiovascular insufficiency. Preliminary blockade of prostaglandins biosynthesis prevent an increase of TbA2 and PG12 blood level, postreperfusion disturbances of central and regional circulation develop later and are less pronounced. Therefore, endogenic prostaglandins take part in the development of post ischemic shock reaction, influencing chiefly the venous vessels and blood return to heart.
对麻醉犬的实验表明，缺血组织再灌注伴随着血栓素A2（Tx A2）和前列环素（PG I2）血液水平的显著升高以及明显的心血管功能不全的发展。前列腺素生物合成的初步阻断可防止TbA2和PG12血液水平升高，再灌注后中枢和局部循环的紊乱出现较晚且不太明显。因此，内源性前列腺素参与缺血后休克反应的发展，主要影响静脉血管和血液回心。
