Zhukova A V, Sahach V F
Fiziol Zh (1994). 1996;42(1-2):3-9.
The role of eicosanoids as one of the main shock mediators was demonstrated in experiments anesthetized dogs with modeled postischemic shock using premedication with indometacin and/or quercetin. Preliminary administration of the eicosanoid biosynthesis inhibitors has prevented reperfusion hemodynamics disturbances during 3 hours after the beginning of an extremity reperfusion. The presented results confirm vascular endothelium injury in the investigated areas, which caused disbalance in the necessity-flow balance in working organs. Therefore, a damage in the endotheliocytes function is the first and, probably, a leading factor in development of the postischemic disturbances of circulation.
