Zhukova A V, Sagach V F
A. Bogomoletz Institute of Physiology, National Academy of Sciences, Kiev, Ukraine.
Pol J Pharmacol. 1996 Jan-Feb;48(1):23-9.
Using premedication with indomethacin and/or quercetin, the role of the eicosanoids as one of the main shock mediators has been demonstrated in anesthetized dogs using a model of postischemic shock. Hemodynamic disturbances were correlated with an increment in eicosanoids blood levels both in time and value courses. The results testify to the vascular endothelium injury in all investigated regions. This event might be a starting point of the disturbances in balance between a necessity and real flow in working organs under shock-like states. Therefore, a damage in endotheliocytes function is the first and may be a leading factor in the development of postischemic disturbances of circulation. Pretreatment with the inhibitors of eicosanoids biosynthesis prevented the reperfusion-evoked hemodynamic disturbances.
使用吲哚美辛和/或槲皮素进行预处理，在缺血后休克模型的麻醉犬中，已证实类二十烷酸作为主要休克介质之一的作用。血流动力学紊乱在时间和数值过程上均与类二十烷酸血水平的升高相关。结果表明在所有研究区域均存在血管内皮损伤。这一事件可能是休克样状态下工作器官中需求与实际血流平衡紊乱的起始点。因此，内皮细胞功能损伤是缺血后循环紊乱发生的首要且可能是主导因素。用类二十烷酸生物合成抑制剂进行预处理可预防再灌注诱发的血流动力学紊乱。
