Zheng Lihui, Yao Yan, Zhang Shu, Chen Wensheng, Zhang Kuijun, Wang Fangzheng, Chen Xin, He Ding Sheng, Kadish Alan H
Clinical EP Laboratory and Arrhythmia Center, Fuwai Hospital and Cardiovascular Institute, Peking Union Medical College (PUMC)-Chinese Academy of Medical Sciences (CAMS), Beijing, China.
J Cardiovasc Electrophysiol. 2009 May;20(5):499-506. doi: 10.1111/j.1540-8167.2008.01371.x. Epub 2008 Nov 21.
This study attempted to delineate the mechanism of organized left atrial tachyarrhythmia (AT) during stepwise linear ablation for atrial fibrillation (AF) using noncontact mapping.
Eighty patients in whom organized ATs developed or induced during stepwise linear ablation for AF were enrolled. Left atrial (LA) activation during ATs was mapped using noncontact mapping. Radiofrequency (RF) energy was delivered to the earliest activation site or narrowest part of the reentrant circuit of ATs. A total of 146 ATs were mapped. Four ATs were characterized as a focal mechanism (cycle length (CL): 225 +/- 49 ms). A macroreentrant mechanism was confirmed in the remaining 142 ATs. LA activation time accounted for 100% of CL (205 +/- 37 ms). All 142 ATs used the conduction gaps in the basic figure-7 lesion line. There were three types of circuits classified based on the gap location. Type I (n = 68) used gaps at the ridge between left atrial appendage (LAA) and left superior pulmonary vein (LSPV). Type II (n = 50) used gaps on the LA roof. Type III (n = 24) passed through gaps in the mitral isthmus. Ablation at these gaps eliminated 130 ATs. During the follow-up period of 16.2 +/- 6.7 months, 82.5% of the 80 patients were in sinus rhythm.
The majority of left ATs developed during stepwise linear ablation for AF are macroreentrant through conduction gaps in the figure-7 lesion line, especially at the LAA-LSPV ridge. Noncontact activation mapping can identify these gaps accurately and quickly to target effective catheter ablation.
本研究试图利用非接触式标测来阐明在心房颤动(AF)的逐步线性消融过程中发生有组织的左房性快速心律失常(AT)的机制。
纳入80例在AF逐步线性消融过程中发生或诱发有组织的AT的患者。使用非接触式标测对AT期间的左房(LA)激动进行标测。将射频(RF)能量传递至AT折返环的最早激动部位或最窄部位。共标测了146次AT。4次AT表现为局灶性机制(周期长度(CL):225±49毫秒)。其余142次AT证实为大折返机制。LA激动时间占CL的100%(205±37毫秒)。所有142次AT均利用了基本的7字形病变线中的传导间隙。根据间隙位置将环路分为三种类型。I型(n = 68)利用左心耳(LAA)与左上肺静脉(LSPV)之间嵴上的间隙。II型(n = 50)利用LA顶部的间隙。III型(n = 24)穿过二尖瓣峡部的间隙。在这些间隙处进行消融消除了130次AT。在16.2±6.7个月的随访期内,80例患者中有82.5%处于窦性心律。
在AF逐步线性消融过程中发生的大多数左房AT是通过7字形病变线中的传导间隙进行大折返,尤其是在LAA-LSPV嵴处。非接触式激动标测可准确、快速地识别这些间隙,以指导有效的导管消融。