Lygidakis N A, Dimou G, Marinou D
Dept of Paediatric Dentistry, Community Dental Center for Children, Athens, Greece.
Eur Arch Paediatr Dent. 2008 Dec;9(4):207-17. doi: 10.1007/BF03262637.
This was to examine the potential medical aetiological factors involved in the development of MIH.
During the years 2003--2005, all MIH cases diagnosed according to set criteria were selected from the new patients clinic of a Community Dental Centre for Children (Athens). The age, gender and teeth involved were recorded. A control group of socio-demographically matched controls was also identified. The potential aetiological factors were retrieved through personal interview with the parents and from each child and mother's medical book. Only verified aetiological factors were recorded. Evaluation of the correlation of affected teeth and the timing of the insult was performed in a separate group of 225 affected children aged 8-12 with their entire 12 'index' teeth erupted.
From the 3,518, 5.5 to 12 years old children examined, 360 (10.2%) had MIH. Aetiology of MIH: 44 children (12.2%), presented without any relevant medical history, the remaining 316 (87.8%) recorded various medical problems associated with MIH, compared with 18.9% for controls. Perinatal (163, 33.6%) and postnatal (162, 33.9%) problems were the most frequently found and prenatal the least (33, 8.6%). For 42 children (11.7%) problems occurred in more than one chronological period, mainly during both the perinatal and postnatal period (11.1%). The most common prenatal problem was repeated episodes of high fever (12/33), in the perinatal period birth by Caesarean section (92/163) and other birth complications (34/163). Various respiratory conditions (88/162), repeated episodes of high fever (31/162) and neonatal illness (28/162) were the commonly reported problems in the postnatal period. Many MIH cases presented with more than one medical problem during the peri-and postnatal period.
Children with MIH recorded 68.9% more frequent medical problems than controls (p<0.0001). A positive correlation (p<0.001) between the total number and type of affected teeth with the timing of the insult was observed in the 225 MIH children with all their 'index' teeth erupted.
Children with MIH present with more medical problems than controls during their prenatal, perinatal and postnatal period. The majority of these illnesses may produce hypocalcaemia, hypoxia and pyrexia to the child or the mother. The number of affected teeth was associated with the timing of the possible insult; children with prenatal, perinatal and postnatal problems present more affected teeth in increasing order.
本研究旨在探讨与乳牙釉质发育不全（MIH）发生相关的潜在医学病因。
在2003年至2005年期间，从一家社区儿童牙科中心（雅典）的新患者诊所中选取所有根据既定标准诊断为MIH的病例。记录患者的年龄、性别及受累牙齿情况。同时确定一组社会人口统计学匹配的对照组。通过与家长的个人访谈以及查阅每个孩子和母亲的病历获取潜在病因。仅记录经证实的病因。在另一组225名年龄8至12岁且12颗“指标”牙全部萌出的患龋儿童中，评估患龋牙齿与损伤发生时间的相关性。
在接受检查的3518名5.5至12岁儿童中，360名（10.2%）患有MIH。MIH的病因：44名儿童（12.2%）无任何相关病史，其余316名（87.8%）记录有与MIH相关的各种医学问题，而对照组为18.9%。围产期问题（163例，33.6%）和产后问题（162例，33.9%）最为常见，产前问题最少（33例，8.6%）。42名儿童（11.7%）在多个时间段出现问题，主要是围产期和产后（11.1%）。最常见的产前问题是反复高热发作（12/33），围产期是剖宫产（92/163）和其他分娩并发症（34/163）。各种呼吸道疾病（88/162）、反复高热发作（31/162）和新生儿疾病（28/162）是产后常见问题。许多MIH病例在围产期和产后出现不止一个医学问题。
MIH患儿记录的医学问题比对照组频繁68.9%（p<0.0001）。在225名所有“指标”牙均已萌出的MIH患儿中，观察到患龋牙齿总数和类型与损伤发生时间呈正相关（p<0.001）。
MIH患儿在产前、围产期和产后比对照组存在更多医学问题。这些疾病中的大多数可能导致患儿或母亲出现低钙血症、缺氧和发热。患龋牙齿数量与可能的损伤时间相关；产前、围产期和产后有问题的儿童患龋牙齿数量依次增多。
