Jones G H, Mittleman G, Robbins T W
Department of Experimental Psychology, University of Cambridge, United Kingdom.
Behav Neural Biol. 1989 Jan;51(1):80-91. doi: 10.1016/s0163-1047(89)90686-9.
The relationship between amphetamine-induced stereotyped behavior and a neuroendocrine index of arousal, plasma corticosterone (CCS), was investigated. 6-Hydroxydopamine lesions of the caudate-putamen, which produced dopamine depletions of 60%, blocked stereotypy and prolonged the elevation in corticosterone associated with d-amphetamine treatment (5 mg/kg). Similar dopamine depleting lesions of the nucleus accumbens, which attenuated the locomotor, but not the stereotypic, response to AMPH did not have this effect on CCS. This pattern of results supports the hypothesis that stereotypy has a coping function which may serve to alter arousal and further suggests important differences between the nigrostriatal and mesolimbic dopamine projections in modulating the responsiveness of the neuroendocrine system. These results have implications for understanding the function of behavioral stereotypies common to a number of psychopathological conditions, including schizophrenia and childhood autism.
研究了苯丙胺诱导的刻板行为与一种唤醒的神经内分泌指标——血浆皮质酮（CCS）之间的关系。尾状核 - 壳核的6 - 羟基多巴胺损伤导致多巴胺耗竭60%，阻断了刻板行为，并延长了与d - 苯丙胺治疗（5毫克/千克）相关的皮质酮升高。伏隔核类似的多巴胺耗竭损伤减弱了对AMPH的运动反应，但未减弱刻板反应，对CCS没有这种作用。这种结果模式支持了刻板行为具有应对功能的假说，该功能可能有助于改变唤醒状态，并进一步表明黑质纹状体和中脑边缘多巴胺投射在调节神经内分泌系统反应性方面存在重要差异。这些结果对于理解包括精神分裂症和儿童自闭症在内的多种精神病理状况中常见的行为刻板的功能具有启示意义。
