Lee N, Radke J M, Vincent S R
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Behav Brain Res. 1988 Jul;29(1-2):179-83. doi: 10.1016/0166-4328(88)90065-4.
Previous studies have suggested that somatostatin neurons in the basal ganglia may be involved in motor activity. In the present experiments, the effects of cysteamine, a drug which reduces somatostatin levels, on the basal and dopamine-mediated motor activities were examined in the rat. Neither intra-striatal nor intra-accumbens infusions of cysteamine had any effect on motor activity prior to the administration of dopamine agonists. However, intra-striatal cysteamine infusions reduced the duration of the stereotypic behavior induced by systemic apomorphine. In addition, intra-accumbens infusions of cysteamine produced a slight reduction in the locomotor response induced by amphetamine. The direct intra-cerebral infusion of cysteamine produced a significant depletion in the levels of somatostatin at the site of injections as measured by radioimmunoassay. These results indicate that somatostatin neurons in the basal ganglia may modulate the motor responses following dopaminergic activation, and further support the presence of a dopamine-somatostatin interaction in this region.
先前的研究表明，基底神经节中的生长抑素神经元可能参与运动活动。在本实验中，研究了半胱胺（一种降低生长抑素水平的药物）对大鼠基础运动活动和多巴胺介导的运动活动的影响。在给予多巴胺激动剂之前，纹状体内或伏隔核内注射半胱胺对运动活动均无影响。然而，纹状体内注射半胱胺可缩短全身注射阿扑吗啡诱导的刻板行为的持续时间。此外，伏隔核内注射半胱胺可使苯丙胺诱导的运动反应略有降低。通过放射免疫测定法测得，直接脑内注射半胱胺可使注射部位的生长抑素水平显著降低。这些结果表明，基底神经节中的生长抑素神经元可能调节多巴胺能激活后的运动反应，并进一步支持该区域存在多巴胺 - 生长抑素相互作用。
