Saha S K
Department of Surgery, Queen Elizabeth Hospital, Gateshead, UK.
Jpn J Cancer Res. 1991 May;82(5):497-502. doi: 10.1111/j.1349-7006.1991.tb01878.x.
Over a period of 8 years, a case-control study was carried out on smoking habits in 117 patients with carcinoma of the stomach and 234 controls, and a significant association of a particular method of smoking with the site of gastric carcinoma was found in the cancer patients. Furthermore, there was a highly significant difference in method of smoking between the cancer patients and the control group. The prevalence of smoking habit in the latter was 37%, of which 26% had swallowed the smoke regularly. In contrast, the incidence of smoking habit in the cancer patients was over 56%, of which 64% had swallowed the tobacco smoke. The difference is highly significant (P less than 0.001). The study also suggests that the distal part, in particular, the antrum of the stomach was affected more frequently among the smokers of the cancer patients who had swallowed the smoke regularly but the cardiac end seemed to be involved more often in the other groups of the cancer patients. These included 'never-smokers,' ex-smokers and those smokers who did not swallow the smoke (P less than 0.01). It is therefore concluded that the swallowing of tobacco smoke seems to influence the site of gastric carcinoma. The relative risk was six-fold higher among the smokers who did swallow the smoke compared with the 'never-smokers' of the control group.
在8年的时间里，对117例胃癌患者和234名对照者的吸烟习惯进行了一项病例对照研究，结果发现癌症患者中一种特定的吸烟方式与胃癌的发病部位存在显著关联。此外，癌症患者与对照组在吸烟方式上存在高度显著差异。对照组吸烟习惯的患病率为37%，其中26%有经常吞咽烟雾的习惯。相比之下，癌症患者吸烟习惯的发生率超过56%，其中64%有吞咽烟草烟雾的习惯。差异具有高度显著性（P小于0.001）。该研究还表明，在经常吞咽烟雾的癌症患者吸烟者中，胃的远端部分，尤其是胃窦，受影响的频率更高，但贲门部在其他癌症患者组中似乎更常受累。这些患者包括“从不吸烟者”、戒烟者以及不吞咽烟雾的吸烟者（P小于0.01）。因此得出结论，吞咽烟草烟雾似乎会影响胃癌的发病部位。与对照组的“从不吸烟者”相比，确实吞咽烟雾的吸烟者的相对风险高出六倍。
