Malakar Mridul, Devi K Rekha, Phukan Rup Kumar, Kaur Tanvir, Deka Manab, Puia Lalhriat, Barua Debajit, Mahanta Jagadish, Narain Kanwar
Regional Medical Research Centre, NE Region (Indian Council of Medical Research), Assam, India.
Asian Pac J Cancer Prev. 2012;13(9):4725-32. doi: 10.7314/apjcp.2012.13.9.4725.
The incidence of stomach cancer in Mizoram is highest in India. We have conducted a population based matched case-control study to identify environmental and genetic risk factors in this geographical area.
A total of 102 histologically confirmed stomach cancer cases and 204 matched healthy population controls were recruited. GSTM1 and GSTT1 genotypes were determined by PCR and H. pylori infections were determined by ELISA.
Tobacco-smoking was found to be an important risk factor for high incidence of stomach cancer in Mizoram. Meiziol (local cigarette) smoking was a more important risk factor than other tobacco related habits. Cigarette, tuibur (tobacco smoke infused water) and betel nut consumption synergistically increased the risk of stomach cancer. Polymorphisms of GSTM1 and GSTT1 genes were not found to be directly associated with stomach cancer in Mizoram. However, they appeared to be effect modifiers. Persons habituated with tobacco smoking and/or tuibur habit had increased risk of stomach cancer if they carried the GSTM1 null genotype and GSTT1 non-null genotype.
Tobacco smoking, especially meiziol is the important risk factor for stomach cancer in Mizoram. GSTM1 and GSTT1 genes modify the effect of tobacco habits. This study is a first step in understanding the epidemiology of stomach cancer in Mizoram, India.
米佐拉姆邦的胃癌发病率在印度最高。我们开展了一项基于人群的配对病例对照研究，以确定该地理区域内的环境和遗传风险因素。
共招募了102例经组织学确诊的胃癌病例和204名配对的健康人群作为对照。通过聚合酶链反应（PCR）确定谷胱甘肽S-转移酶M1（GSTM1）和谷胱甘肽S-转移酶T1（GSTT1）基因型，通过酶联免疫吸附测定（ELISA）确定幽门螺杆菌感染情况。
在米佐拉姆邦，吸烟被发现是胃癌高发的一个重要风险因素。吸食梅齐奥尔（当地香烟）比其他与烟草相关的习惯是更重要的风险因素。吸烟、饮用图伊布尔（注入烟草烟雾的水）和食用槟榔协同增加了患胃癌的风险。在米佐拉姆邦，未发现GSTM1和GSTT1基因多态性与胃癌直接相关。然而，它们似乎是效应修饰因子。有吸烟和/或饮用图伊布尔习惯的人，如果携带GSTM1无效基因型和GSTT1非无效基因型，患胃癌的风险会增加。
吸烟，尤其是吸食梅齐奥尔，是米佐拉姆邦胃癌的重要风险因素。GSTM1和GSTT1基因改变了烟草习惯的影响。本研究是了解印度米佐拉姆邦胃癌流行病学的第一步。
