Mollnes T E, Castellheim A, Lindenskov P H H, Salvesen B, Saugstad O D
Institute of Immunology, Rikshospitalet, Oslo, Norway.
J Perinatol. 2008 Dec;28 Suppl 3:S116-9. doi: 10.1038/jp.2008.148.
The complement system is part of the host defense with a number of biological effects, most of which contribute to the inflammatory reaction by activation of cells like leukocytes and endothelial cells. An intact complement system is required for protection against infection and for maintaining internal inflammatory homeostasis. However, the system is a double-edged sword as improperly or uncontrolled activation is disadvantageous and potentially harmful for the host. Meconium aspiration syndrome (MAS) is associated with a local inflammatory reaction in the lungs, frequently described as a chemical pneumonitis. Cytokines, arachidonic acid metabolites and reactive oxygen species are involved in this reaction. We have recently documented that meconium is a potent activator of complement in vitro and in an experimental piglet model of MAS, the latter presenting with an inflammatory profile closely resembling systemic inflammatory response syndrome. We postulate that complement activation may contribute to the pathogenesis of MAS.
补体系统是宿主防御的一部分，具有多种生物学效应，其中大多数通过激活白细胞和内皮细胞等细胞来促进炎症反应。完整的补体系统对于预防感染和维持体内炎症稳态至关重要。然而，该系统是一把双刃剑，因为不当或不受控制的激活对宿主不利且可能有害。胎粪吸入综合征（MAS）与肺部的局部炎症反应有关，常被描述为化学性肺炎。细胞因子、花生四烯酸代谢产物和活性氧参与了这一反应。我们最近记录到，胎粪在体外是补体的强效激活剂，在MAS的实验仔猪模型中也是如此，后者呈现出与全身炎症反应综合征极为相似的炎症特征。我们推测补体激活可能有助于MAS的发病机制。
