Zepeda Ortega Benjamín, Ito Tsuchiya Fernando M, Espinola Reyna Gerardo A, Adell Gras A, del Río Navarro Blanca E
Departamento de alergia e inmunología clínica pediátrica, Hospital Infantil de México Federico Gómez, México DF.
Rev Alerg Mex. 2008 May-Jun;55(3):92-102.
Anomalies in pulmonary function tests in obese are oriented predominantly to restrictive pathology, not been demonstrated efficiently.
To determine and compare pulmonary function tests (PFT) with anthropometric measurements by spirometry and plethysmograph in asthmatic obese (AO) and non-asthmatic obese (NAO) adolescents.
Cross-sectional study, with 86 adolescents. Obesity was defined as body mass index (BMI) greater to 95% percentile according to CDC and asthma, on the basis of the definition and criteria of GINA guidelines. Clinical history was made, doing anthropometric measures and PFT with determination of: forced vital capacity with maximal expiratory effort, forced expiratory volume in the first second, specific resistance and conductance.
The average age was 12.68 years +/- 1.85, 39 were NAO and 47 AO, who had intermittent to persistent asthma, 14 patients received 200 mcg budesonide/day at least 4 weeks previous to the study. The average values in AO and their standard error for anthropometry were: weight: 68.5 +/- 13.6 kg, height: 154.58 +/- 9.1 cm, BMI: 28.27 +/- 3.24 kg/m2, abdominal circumference (AC): 98 +/- 8.85 cm and hip circumference (HC): 100 +/- 8.87 cm, in NAO: weight: 76.1 +/- 14.7 kg, height: 155.7 +/- 7.85 cm, BMI: 31.04 +/- 4.46 kg/m2, AC: 102 +/- 11.05 cm and HC: 103.28 +/- 10.6 cm.
In NAO post-beta2 Raw diminished whereas Sgaw increased. Greater BMI in AO displayed greater FEV1 with statistic significance. Obstructive ventilator pattern mechanics was observed in both groups.
肥胖人群肺功能测试异常主要表现为限制性病变，但尚未得到有效证实。
通过肺活量测定法和体积描记法，确定并比较哮喘肥胖青少年（AO）和非哮喘肥胖青少年（NAO）的肺功能测试（PFT）与人体测量指标。
对86名青少年进行横断面研究。根据美国疾病控制与预防中心（CDC）的标准，肥胖定义为体重指数（BMI）高于第95百分位数；哮喘则依据全球哮喘防治创议（GINA）指南的定义和标准来判定。记录临床病史，进行人体测量和肺功能测试，测定指标包括：最大呼气努力时的用力肺活量、第1秒用力呼气量、比气道阻力和比气道传导率。
平均年龄为12.68岁±1.85岁，其中39名是非哮喘肥胖青少年，47名是哮喘肥胖青少年，后者患有间歇性至持续性哮喘，14名患者在研究前至少4周每天接受200微克布地奈德治疗。哮喘肥胖青少年的人体测量平均数值及其标准误为：体重：68.5±13.6千克，身高：154.58±9.1厘米，BMI：28.27±3.24千克/平方米，腹围（AC）：98±8.85厘米，臀围（HC）：100±8.87厘米；非哮喘肥胖青少年的相应数值为：体重：76.1±14.7千克，身高：155.7±7.85厘米，BMI：31.04±4.46千克/平方米，AC：102±11.05厘米，HC：103.28±10.6厘米。
在非哮喘肥胖青少年中，β2后气道阻力降低，而比气道传导率增加。哮喘肥胖青少年中较高的BMI显示出具有统计学意义的更高的第1秒用力呼气量。两组均观察到阻塞性通气模式机制。
