Kim Hyun-Soo, Sung Wooseok, Lee Sun, Chang Sung-Goo, Park Yong-Koo
Department of Pathology, Kyung Hee Medical Center, School of Medicine, Kyung Hee University, #1 Hoegi Dong, Dongdaemoon-gu, Seoul 130-702, Republic of Korea.
Pathol Res Pract. 2009;205(4):249-54. doi: 10.1016/j.prp.2008.10.005. Epub 2008 Dec 6.
Although lymphatic vessel density (LVD) is associated with regional lymph node (LN) metastasis in prostate adenocarcinoma, no study is available that examines whether the LVD is correlated with prognostic factors other than LN metastasis in LN-negative prostate adenocarcinoma. The aim of our study was to analyze intratumoral (IT), peritumoral (PT), and nontumoral (NT) LVDs, and to determine if there is a correlation between the LVD and the clinicopathological parameters in the Korean LN-negative prostate adenocarcinoma patients. Lymphatics were detected by immunohistochemical staining using D2-40 antibody on 39 radical prostatectomy specimens. Mean LVDs of IT, PT, and NT compartments were 5.39+/-4.22, 10.71+/-4.61, and 2.04+/-1.34 per 200 x field, respectively. The difference in LVD among the compartments was significant (P<0.001). The IT-LVD was significantly lower in patients with larger tumor volume (P=0.029) and higher preoperative prostate-specific antigen level (P=0.008). The PT-LVD showed no significant correlation with the clinicopathological parameters. Our results suggest that IT- and PT-LVDs may increase in LN-negative prostate adenocarcinoma as a result of lymphangiogenesis, but IT lymphatics may decrease due to mechanical compression and destruction caused by proliferating tumor cells. In addition, IT-LVD may be used as a prognostic factor in LN-negative prostate adenocarcinoma.
尽管淋巴管密度（LVD）与前列腺腺癌的区域淋巴结（LN）转移相关，但尚无研究探讨LVD是否与LN阴性前列腺腺癌中LN转移以外的预后因素相关。我们研究的目的是分析肿瘤内（IT）、肿瘤周围（PT）和非肿瘤（NT）的LVD，并确定韩国LN阴性前列腺腺癌患者的LVD与临床病理参数之间是否存在相关性。使用D2-40抗体对39例前列腺癌根治术标本进行免疫组化染色检测淋巴管。IT、PT和NT区域的平均LVD分别为每200倍视野5.39±4.22、10.71±4.61和2.04±1.34。各区域之间的LVD差异具有统计学意义（P<0.001）。肿瘤体积较大（P=0.029）和术前前列腺特异性抗原水平较高（P=0.008）的患者IT-LVD显著降低。PT-LVD与临床病理参数无显著相关性。我们的结果表明，在LN阴性前列腺腺癌中，IT和PT的LVD可能由于淋巴管生成而增加，但IT淋巴管可能因增殖的肿瘤细胞引起的机械压迫和破坏而减少。此外，IT-LVD可作为LN阴性前列腺腺癌的预后因素。
