Department of Oncology, Wuhan General Hospital of Guangzhou Command, People's Liberation Army, 430070, Wuhan, Hubei Province, China.
Med Oncol. 2011 Dec;28(4):1447-52. doi: 10.1007/s12032-010-9638-5. Epub 2010 Jul 30.
Tumor-associated macrophages (TAMs) have been implicated in promoting tumor progression. Nowadays, adenocarcinoma has surpassed squamous cell carcinoma as the most frequent type of lung cancer, but in lung adenocarcinoma, the correlation of TAMs with lymphangiogenesis patients remains unclear. The aim of this study was to examine the relationship between TAMs and lymphangiogenesis and the lung adenocarcinoma patients' prognosis. Tumor specimens from 65 patients with lung adenocarcinoma were determined for TAMs count and lymphatic microvessel density (LMVD) by immunohistochemistry. A positive correlation existed between TAMs count and D2-40-positive peritumoral LMVD (r=0.069, P<0.001). TAMs infiltration was significantly associated with P-TNM staging (P=0.042) and lymph node metastasis (P=0.037), and peritumoral LMVD was correlated with lymph node metastasis (P=0.003). A significant difference in overall survival was detected not only between tumors with a high TAMs count and a low TAMs count (P=0.009) but also between tumors with a high peritumoral LMVD and a low peritumoral LMVD (P=0.005). Both TAMs count and peritumoral LMVD were independent prognostic factors for overall survival. Our results indicate that TAMs infiltration correlates with tumor lymphangiogenesis and poor survival in lung adenocarcinoma.
肿瘤相关巨噬细胞（TAMs）被认为与促进肿瘤进展有关。如今，腺癌已超过鳞癌成为最常见的肺癌类型，但在肺腺癌中，TAMs 与淋巴管生成患者的相关性尚不清楚。本研究旨在探讨 TAMs 与淋巴管生成与肺腺癌患者预后的关系。通过免疫组织化学方法检测了 65 例肺腺癌患者肿瘤标本中的 TAMs 计数和淋巴管密度（LMVD）。TAMs 计数与 D2-40 阳性肿瘤周围 LMVD 呈正相关（r=0.069，P<0.001）。TAMs 浸润与 P-TNM 分期（P=0.042）和淋巴结转移（P=0.037）显著相关，肿瘤周围 LMVD 与淋巴结转移相关（P=0.003）。高 TAMs 计数和低 TAMs 计数之间（P=0.009）以及高肿瘤周围 LMVD 和低肿瘤周围 LMVD 之间（P=0.005）的总生存率存在显著差异。TAMs 计数和肿瘤周围 LMVD 均是总生存率的独立预后因素。我们的研究结果表明，TAMs 浸润与肺腺癌的肿瘤淋巴管生成和不良预后相关。
