Zhang Bi-Cheng, Guan Sha, Zhang Ya-Fei, Yao Guo-Qing, Yang Bo, Zhao Yong, Rao Zhi-Guo, Gao Jian-Fei
Department of Oncology, Wuhan General Hospital of Guangzhou Command, People's Liberation Army, Wuhan 430070, P.R. China.
Exp Ther Med. 2012 Apr;3(4):636-640. doi: 10.3892/etm.2012.470. Epub 2012 Feb 3.
Although recent investigations have identified that lymphangiogenesis is associated with regional lymph node metastasis and tumor prognosis in non-small cell lung cancer (NSCLC), peritumoral lymphatic microvessel density (LMVD) and its prognostic significance in lung adenocarcinoma remain unknown. In the present study, we assessed peritumoral LMVD in lung adenocarcinoma and investigated its correlation with patient prognosis. Using immunohistochemistry (SP method), the D2-40-positive peritumoral LMVD count in lung adenocarcinoma was found to be 11.56±10.73, which was higher than intratumoral LMVD (P<0.001), and was found to be associated with lymphatic metastasis (P=0.003) and pTNM staging (P=0.046). Furthermore, a significant difference in the patient overall survival time was demonstrated between tumors with a high peritumoral LMVD and those with a low peritumoral LMVD (P=0.005). Finally, using multivariate analysis, it was determined that peritumoral LMVD, lymphatic metastasis and pTNM staging were independent prognostic factors. In conclusion, the results suggest that D2-40-positive peritumoral LMVD may predict the prognosis of lung adenocarcinoma.
尽管最近的研究已经确定淋巴管生成与非小细胞肺癌（NSCLC）的区域淋巴结转移和肿瘤预后相关，但肿瘤周围淋巴管微血管密度（LMVD）及其在肺腺癌中的预后意义仍不清楚。在本研究中，我们评估了肺腺癌肿瘤周围的LMVD，并研究了其与患者预后的相关性。采用免疫组织化学（SP法），发现肺腺癌肿瘤周围D2-40阳性的LMVD计数为11.56±10.73，高于肿瘤内LMVD（P<0.001），且与淋巴转移（P=0.003）和pTNM分期（P=0.046）相关。此外，肿瘤周围LMVD高的患者与肿瘤周围LMVD低的患者的总生存时间存在显著差异（P=0.005）。最后，通过多因素分析确定，肿瘤周围LMVD、淋巴转移和pTNM分期是独立的预后因素。总之，结果表明D2-40阳性的肿瘤周围LMVD可能预测肺腺癌的预后。
