Moutevelis Efrosini, Woolfson Derek N
School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.
J Mol Biol. 2009 Jan 23;385(3):726-32. doi: 10.1016/j.jmb.2008.11.028. Epub 2008 Nov 25.
Coiled coils are protein structure domains with two or more alpha-helices packed together via interlacing of side chains known as knob-into-hole packing. We analysed and classified a large set of coiled-coil structures using a combination of automated and manual methods. This led to a systematic classification that we termed a "periodic table of coiled coils," which we have made available at http://coiledcoils.chm.bris.ac.uk/ccplus/search/periodic_table. In this table, coiled-coil assemblies are arranged in columns with increasing numbers of alpha-helices and in rows of increased complexity. The table provides a framework for understanding possibilities in and limits on coiled-coil structures and a basis for future prediction, engineering and design studies.
卷曲螺旋是一种蛋白质结构域，由两条或更多条α螺旋通过侧链交错堆积在一起，这种堆积方式被称为旋钮-入-孔堆积。我们结合自动化和手动方法，对一大批卷曲螺旋结构进行了分析和分类。这产生了一种系统的分类，我们称之为“卷曲螺旋周期表”，该表可在http://coiledcoils.chm.bris.ac.uk/ccplus/search/periodic_table获取。在这个表中，卷曲螺旋组装体按α螺旋数量增加的列排列，按复杂度增加的行排列。该表为理解卷曲螺旋结构的可能性和局限性提供了一个框架，也是未来预测、工程和设计研究的基础。
