Arida Ricardo Mario, Scorza Fulvio Alexandre, Scorza Carla Alessandra, Cavalheiro Esper Abrão
Departamento de Fisiologia, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), Rua Botucatú 862, Ed. Ciências Biomédicas 5(0) andar, CEP 04023-900 São Paulo, Brazil.
Neurosci Biobehav Rev. 2009 Mar;33(3):422-31. doi: 10.1016/j.neubiorev.2008.11.002. Epub 2008 Nov 18.
Exposure to different physical and cognitive stimulus have been shown to induce extensive neuronal plasticity in both undamaged and injured central nervous system, such as enhanced neurogenesis in the dentate gyrus of the hippocampus, up-regulation of neurotrophic factors and improved learning and memory. Neuronal plasticity also is found during certain neurodegenerative conditions, including the temporal lobe epilepsy (TLE). TLE is the most common form of partial epilepsy, characterized by atrophy of mesial temporal structures, mossy fiber sprouting, spontaneous recurrent seizures and cognitive deficits. In view of the fact that physical activity has been found to be beneficial for treating animal models of Parkinson's, Alzheimer's and Huntington's diseases, there is considerable interest in determining the efficacy of this strategy for preventing or treating chronic TLE. This review discusses the positive effects of program of physical exercise in experimental models of epilepsy. Thus, considerations of the potential application of physical exercise strategy for preventing or treating TLE are highlighted.
已表明，接触不同的身体和认知刺激可在未受损和受损的中枢神经系统中诱导广泛的神经元可塑性，如海马齿状回中神经发生增强、神经营养因子上调以及学习和记忆改善。在某些神经退行性疾病中也发现了神经元可塑性，包括颞叶癫痫（TLE）。TLE是最常见的部分性癫痫形式，其特征为内侧颞叶结构萎缩、苔藓纤维出芽、自发性反复癫痫发作和认知缺陷。鉴于已发现体育活动对治疗帕金森病、阿尔茨海默病和亨廷顿病的动物模型有益，人们对确定该策略预防或治疗慢性TLE的疗效有相当大的兴趣。本综述讨论了体育锻炼方案在癫痫实验模型中的积极作用。因此，突出了对体育锻炼策略预防或治疗TLE潜在应用的考虑。
