Bouyahya Abdelhakim, Balahbib Abdelaali, Khalid Asaad, Makeen Hafiz A, Alhazmi Hassan A, Albratty Mohammed, Hermansyah Andi, Ming Long Chiau, Goh Khang Wen, El Omari Nasreddine
Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10106, Morocco.
Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, 60115 Surabaya, Indonesia.
Heliyon. 2024 Apr 16;10(9):e29718. doi: 10.1016/j.heliyon.2024.e29718. eCollection 2024 May 15.
Diabetes is a complex disease that affects a large percentage of the world's population, and it is associated with several risk factors. Self-management poses a significant challenge, but natural sources have shown great potential in providing effective glucose reducing solutions. Flavonoids, a class of bioactive substances found in different natural sources including medicinal plants, have emerged as promising candidates in this regard. Indeed, several flavonoids, including apigenin, arbutin, catechins, and cyanidin, have demonstrated remarkable anti-diabetic properties. The clinical effectiveness of these flavonoids is linked to their potential to decrease blood glucose concentration and increase insulin concentration. Thus, the regulation of certain metabolic pathways such as glycolysis and neoglycogenesis has also been demonstrated. and investigations revealed different mechanisms of action related to flavonoid compounds at subcellular, cellular, and molecular levels. The main actions reside in the activation of glycolytic signaling pathways and the inhibition of signaling that promotes glucose synthesis and storage. In this review, we highlight the clinical efficiency of natural flavonoids as well as the molecular mechanisms underlying this effectiveness.
糖尿病是一种复杂的疾病，影响着世界上很大一部分人口，并且与多种风险因素相关。自我管理是一项重大挑战，但天然来源在提供有效的降血糖解决方案方面已显示出巨大潜力。黄酮类化合物是一类存在于包括药用植物在内的不同天然来源中的生物活性物质，在这方面已成为有前景的候选物。事实上，包括芹菜素、熊果苷、儿茶素和花青素在内的几种黄酮类化合物已表现出显著的抗糖尿病特性。这些黄酮类化合物的临床有效性与其降低血糖浓度和提高胰岛素浓度的潜力有关。因此，某些代谢途径如糖酵解和新糖生成的调节也已得到证实。研究揭示了黄酮类化合物在亚细胞、细胞和分子水平上不同的作用机制。主要作用在于激活糖酵解信号通路以及抑制促进葡萄糖合成和储存的信号传导。在本综述中，我们强调了天然黄酮类化合物的临床疗效以及这种有效性背后的分子机制。
