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一种从西班牙赫罗纳健康地区的行政初级卫生保健数据库中估算高血压患病率且无选择偏倚的方法。

A selection-bias free method to estimate the prevalence of hypertension from an administrative primary health care database in the Girona Health Region, Spain.

作者信息

Saez Marc, Barceló Maria Antònia, Coll de Tuero Gabriel

机构信息

Research Group on Statistics, Applied Economics and Health, GRECS, University of Girona, Spain.

出版信息

Comput Methods Programs Biomed. 2009 Mar;93(3):228-40. doi: 10.1016/j.cmpb.2008.10.010. Epub 2008 Dec 6.

Abstract

The prevalence of common illnesses could be estimated using general practice databases, providing certain advantages when compared to other alternative sources of information, in particular being relatively more cost-effective. The main limitation is that it is a threat of selection bias. Some individuals have a higher probability of having used primary health care, implying that the potential result, 'contact registration', is overrepresented in the sample observed. The selection bias would provide inconsistent estimators of prevalence. The objective of this study is to propose a bias-free selection method to estimate prevalence using an administrative primary health care database. It proposes re-weighting the estimations of prevalence obtained from the database according to the probability of their being present in the same. These probabilities will be appropriately estimated from a health survey using a treatment effects model with a discrete response, i.e. a hurdle model. As an application, it was estimated the prevalence of hypertension in the population covered by public primary health care providers in the Girona Health Region, Spain, in 2005. Using this bias-free selection method the prevalence of hypertension has been estimated that 15.5% of individuals aged 15 and above (14.1% among men and 16.9% among women) suffer from hypertension. Likewise, the prevalence is estimated at 31.1% (30.3% men and 32.0% women) in individuals aged 45 and over; 48.3% (44.1% men and 51.9% women) among those aged 65 and over; and 13.1% (11.8% men and 13.9% women) in the general population. The proposed method provides estimators of the prevalence of hypertension very close to those obtained directly from the 2006 Catalan Health Survey. It is concluded that the proposed method could be used to estimate the prevalence of hypertension in an approximately unbiased form. Given the use of the administrative primary health care database corresponding to all users of primary health care in the 23 public managed Health Areas of the Girona Health Region during 2005, the proposed method will be more cost-effective and will provide much more population information than health questionnaires.

摘要

利用全科医疗数据库可以估算常见疾病的患病率,与其他替代信息来源相比,具有一定优势,特别是相对更具成本效益。主要局限性在于存在选择偏倚的风险。一些人使用初级卫生保健的概率较高,这意味着在观察样本中,潜在结果“接触登记”被过度代表。选择偏倚会导致患病率估计值不一致。本研究的目的是提出一种无偏选择方法,利用行政初级卫生保健数据库估算患病率。该方法建议根据数据库中出现的概率对从数据库获得的患病率估计值进行重新加权。这些概率将通过使用具有离散响应的治疗效果模型(即障碍模型)从健康调查中适当估计。作为应用,估算了2005年西班牙赫罗纳健康地区公共初级卫生保健提供者覆盖人群中的高血压患病率。使用这种无偏选择方法,估计15岁及以上人群中15.5%(男性为14.1%,女性为16.9%)患有高血压。同样,45岁及以上人群的患病率估计为31.1%(男性为30.3%,女性为32.0%);65岁及以上人群中为48.3%(男性为44.1%,女性为51.9%);普通人群中为13.1%(男性为11.8%,女性为13.9%)。所提出的方法提供的高血压患病率估计值与直接从2006年加泰罗尼亚健康调查中获得的估计值非常接近。得出的结论是,所提出的方法可用于以近似无偏的形式估计高血压患病率。鉴于使用了与2005年赫罗纳健康地区23个公共管理健康区域的所有初级卫生保健使用者相对应的行政初级卫生保健数据库,所提出的方法将更具成本效益,并且比健康问卷提供更多的人群信息。

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