2,5-二氧代-1,2,5,6,7,8-六氢-3-喹啉甲腈文库的快速三步一锅法微波辅助合成

Rapid three-step one-pot microwave-assisted synthesis of 2,5-dioxo-1,2,5,6,7,8-hexahydro-3-quinolinecarbonitrile library.

作者信息

Yermolayev Sergey A, Gorobets Nikolay Yu, Desenko Sergey M

机构信息

Department of Chemistry of Heterocyclic Compounds, SSI Institute for Single Crystals of National Academy of Sciences of Ukraine, Kharkiv, Ukraine.

出版信息

J Comb Chem. 2009 Jan-Feb;11(1):44-6. doi: 10.1021/cc800118v.

DOI:10.1021/cc800118v

PMID:19061393

Abstract

Many well-known drugs contain 2-pyridone and 2-quinolone scaffolds. In the current paper, a one-pot three-step microwave-assisted method for the synthesis of N1-substituted 2,5-dioxo-1,2,5,6,7,8-hexahydro-3-quinolinecarbonitrile derivatives was developed. Employing this protocol, we quickly generated 105 compounds library from 1,3-cyclohexanediones, dimethylformamide dimethylacetal, and various cyanacetamides.

摘要

许多知名药物都含有2-吡啶酮和2-喹啉酮骨架。在本文中，开发了一种用于合成N1-取代的2,5-二氧代-1,2,5,6,7,8-六氢-3-喹啉甲腈衍生物的一锅三步微波辅助方法。采用该方法，我们从1,3-环己二酮、二甲基甲酰胺二甲基缩醛和各种氰基乙酰胺快速生成了一个包含105种化合物的库。