Acevedo Lisette M, Cheresh David A
Department of Pathology and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093-0803, USA.
Cancer Cell. 2008 Dec 9;14(6):429-30. doi: 10.1016/j.ccr.2008.11.009.
Infantile hemangiomas represent the most common tumor of endothelial cell (EC) origin, yet the mechanisms regulating hemangioma EC behavior are poorly understood. A new study by Jinnin et al. demonstrates that enhanced VEGFR2 signaling in hemangioma ECs is caused by suppression of NFAT (nuclear factor of activated T cells)-dependent VEGFR1 expression.
婴儿血管瘤是内皮细胞（EC）来源最常见的肿瘤，然而调节血管瘤内皮细胞行为的机制却知之甚少。Jinnin等人的一项新研究表明，血管瘤内皮细胞中VEGFR2信号增强是由NFAT（活化T细胞核因子）依赖性VEGFR1表达受抑制所致。
