光动力疗法在整形与重建外科中的应用。

The application of photodynamic therapy in plastic and reconstructive surgery.

作者信息

Wu Min, Huang Xiaoyu, Gao Lu, Zhou Guoyu, Xie Feng

机构信息

Department of Plastic and Reconstructive Surgery, School of Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

出版信息

Front Chem. 2022 Jul 22;10:967312. doi: 10.3389/fchem.2022.967312. eCollection 2022.

DOI:10.3389/fchem.2022.967312

PMID:35936104

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9353173/

Abstract

Photodynamic therapy (PDT) is a modern clinical treatment paradigm with the advantages of high selectivity, non-invasiveness, rare side-effect, no obvious drug resistance and easy combination with other therapies. These features have endowed PDT with high focus and application prospects. Studies of photodynamic therapy have been expanded in a lot of biomedical and clinical fields, especially Plastic and Reconstructive Surgery (PRS) the author major in. In this review, we emphasize the mechanism and advances in PDT related to the PRS applications including benign pigmented lesions, vascular malformations, inflammatory lesions, tumor and others. Besides, combined with clinical data analysis, the limitation of PDT and current issues that need to be addressed in the field of PRS have also been discussed. At last, a comprehensive discussion and outlooking represent future progress of PDT in PRS.

摘要

光动力疗法（PDT）是一种现代临床治疗模式，具有高选择性、非侵入性、副作用少、无明显耐药性且易于与其他疗法联合使用等优点。这些特性赋予了光动力疗法高度的关注度和应用前景。光动力疗法的研究已在许多生物医学和临床领域展开，尤其是作者所从事的整形与重建外科（PRS）领域。在本综述中，我们着重阐述了与PRS应用相关的光动力疗法的机制和进展，包括良性色素沉着病变、血管畸形、炎性病变、肿瘤等。此外，结合临床数据分析，还讨论了光动力疗法的局限性以及PRS领域当前需要解决的问题。最后，进行了全面的讨论和展望，展现了光动力疗法在PRS领域的未来进展。