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多囊卵巢综合征中肥胖的治疗:雄激素过多和多囊卵巢综合征学会的立场声明。

Treatment of obesity in polycystic ovary syndrome: a position statement of the Androgen Excess and Polycystic Ovary Syndrome Society.

机构信息

The Jean Hailes Foundation for Women's Health, Monash Institute of Health Services Research, Monash University, Melbourne, Victoria, Australia.

出版信息

Fertil Steril. 2009 Dec;92(6):1966-82. doi: 10.1016/j.fertnstert.2008.09.018. Epub 2008 Dec 4.

Abstract

OBJECTIVE

To summarize current evidence on lifestyle management (dietary, exercise, or behavioral interventions) of obesity in women with polycystic ovary syndrome (PCOS), to indicate gaps in knowledge, and to review the medical and surgical alternatives for weight management.

DESIGN

Expert panel appointed by the Androgen Excess and PCOS Society (AEPCOS Society) to review the literature and draft the initial report after a consensus process via electronic communication. The initial report was reviewed and critiqued by all expert panel members and the AEPCOS Society Board of Directors and modified based on their comments.

CONCLUSION(S): Lifestyle management should be used as the primary therapy in overweight and obese women with PCOS for the treatment of metabolic complications. For reproductive abnormalities, lifestyle modification may improve ovulatory function and pregnancy. Data are preliminary for improvement in pregnancy and live-birth rates, and further research is needed. There is currently no evidence that modifying dietary macronutrient composition offers additional benefits over conventional dietary approaches for weight loss, and further research is needed. Emerging evidence suggests that exercise offers additional benefits to dietary energy restriction for reproductive features of PCOS.

摘要

目的

总结多囊卵巢综合征(PCOS)女性肥胖的生活方式管理(饮食、运动或行为干预)的现有证据,指出知识空白,并回顾用于体重管理的医学和手术选择。

设计

雄激素过多和 PCOS 学会(AEPCOS 学会)任命的专家小组通过电子通信达成共识后,对文献进行审查并起草初步报告。初步报告由所有专家小组成员以及 AEPCOS 学会理事会进行审查和批评,并根据他们的意见进行修改。

结论

生活方式管理应作为超重和肥胖 PCOS 女性的主要治疗方法,用于治疗代谢并发症。对于生殖异常,生活方式的改变可能会改善排卵功能和妊娠。改善妊娠和活产率的数据尚处于初步阶段,需要进一步研究。目前没有证据表明改变膳食宏量营养素组成比常规饮食方法更有利于减肥,还需要进一步的研究。新出现的证据表明,运动除了限制饮食能量外,对 PCOS 的生殖特征还有额外的益处。

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