Swartz M A, Welch D F, Narayanan R P, Greenfield R A
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
Am J Clin Pathol. 1991 Jul;96(1):130-3. doi: 10.1093/ajcp/96.1.130.
A 63-year-old previously healthy woman presented with acute meningitis. Cultures of the cerebrospinal fluid yielded a serotype 1/2a isolate of Listeria monocytogenes that was biochemically typical in all respects, other than the reproducible lack of catalase production. During therapy, the patient developed oculomotor dysfunction that was attributed to an abscess in the internal capsule. This case report documents the existence of catalase-negative L. monocytogenes indicating that catalase production should not be a strict criterion for identification of Listeria. Furthermore, this clinical experience extends in vitro and experimental animal studies indicating that catalase production is not a necessary virulence factor for invasion by Listeria.
一名63岁既往健康的女性出现急性脑膜炎。脑脊液培养分离出一株1/2a血清型单核细胞增生李斯特菌，除了始终无法产生过氧化氢酶外，该菌株在各方面生化特性均典型。治疗期间，患者出现动眼神经功能障碍，归因于内囊脓肿。本病例报告记录了过氧化氢酶阴性的单核细胞增生李斯特菌的存在，表明过氧化氢酶产生不应作为鉴定李斯特菌的严格标准。此外，这一临床经验扩展了体外和实验动物研究，表明过氧化氢酶产生并非李斯特菌侵袭所必需的毒力因子。
