Chingin Konstantin, Chen Huanwen, Gamez Gerardo, Zhu Liang, Zenobi Renato
Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland.
Anal Chem. 2009 Jan 1;81(1):123-9. doi: 10.1021/ac801572d.
Recent findings suggest that long-term exposure to diethyl phthalate (DEP), one of the widely used phthalate esters, can lead to serious health problems. Most perfumes contain non-negligible amounts of DEP. Rapid and sensitive detection of DEP in perfumes is thus of increasing importance. A novel procedure based on extractive electrospray ionization mass spectrometry (EESI-MS) has been developed for fast detection and identification of DEP in perfumes without the need for any sample pretreatment. The limit of determination for DEP in perfume was less than 100 ppb using tandem mass spectrometry on a commercial quadrupole time-of-flight mass spectrometer. The dynamic range of this method was about 4 orders of magnitude. A single sample analysis was completed within a few seconds, providing a rapid way to obtain semiquantitative information on the DEP content in perfumes. This study shows that both volatile and nonvolatile analytes (e.g., amino acids) in liquids can be directly sampled by neutral desorption, providing a convenient way for high-throughput screening of target compounds using EESI-MS.
最近的研究结果表明，长期接触邻苯二甲酸二乙酯（DEP），一种广泛使用的邻苯二甲酸酯，可能会导致严重的健康问题。大多数香水都含有不可忽视量的DEP。因此，快速灵敏地检测香水中的DEP变得越来越重要。一种基于萃取电喷雾电离质谱（EESI-MS）的新方法已被开发出来，用于快速检测和鉴定香水中的DEP，无需任何样品预处理。在商用四极杆飞行时间质谱仪上使用串联质谱法，香水中DEP的测定限小于100 ppb。该方法的动态范围约为4个数量级。单个样品分析在几秒钟内即可完成，为获取香水中DEP含量的半定量信息提供了一种快速方法。这项研究表明，液体中的挥发性和非挥发性分析物（如氨基酸）都可以通过中性解吸直接采样，为使用EESI-MS高通量筛选目标化合物提供了一种便捷的方法。
