Toxicology and Multipurpose Lab., Anti Doping Lab. Qatar, P.O. Box 27775, Doha, Qatar.
Environ Sci Pollut Res Int. 2019 Jan;26(1):421-430. doi: 10.1007/s11356-018-3604-8. Epub 2018 Nov 7.
Phthalates are ubiquitous semi-volatile organic compounds in the indoor environment present in various consumer products such as cosmetics, polyvinylchloride (PVC) flooring, food packing, and many others. Indoor phthalate concentrations were investigated in 15 buildings including 11 homes, 3 laboratories, and 1 from a hospital in Qatar. Dust samples were collected from vacuum cleaning bags usually used for cleaning homes, labs, and hospitals. The main objectives of this study was to determine the occurrence and concentration of phthalates in dust in Qatar and consequently to estimate the non-dietary human exposure. Eleven phthalates was analyzed. The major identified phthalate compounds at homes in Qatar were bis(2-ethylhexyl) phthalate unlabeled (DEHP) and diisononyl phthalate (DINP) at a geometric mean of 288 μg/g (median 395 μg/g) and 106 μg/g (median 101 μg/g) accounting for 57% and 23% of the total measured phthalates, respectively. The major phthalate compounds found in the first lab building were DEHP and DINP with a median of 4861 μg/g and 943 μg/g, respectively, accounting for 82% and 16% of the total phthalates. For the second lab building, the major phthalates were DEHP with a median of 466 μg/g, accounting for 20% of the total phthalates measured, and DINP median of 1725 μg/g, accounting for 71% of the total measured phthalates. The dust sample tested from hospital building had DEHP as the major phthalate compound with a median of 793 μg/g, accounting for 4.0% of the total measured phthalates, and DINP with a median of 19,626 μg/g, accounting for 94%. The estimated human non-dietary exposure for children, adults, and toddlers was based on phthalate concentrations (median) and found to be 225 ng/kg bw/day for children, 2328 ng/kg bw/day for adults, and 2099 ng/kg bw/day for toddlers.
邻苯二甲酸酯是室内环境中普遍存在的半挥发性有机化合物，存在于各种消费品中，如化妆品、聚氯乙烯（PVC）地板、食品包装等。在卡塔尔的 15 座建筑中进行了室内邻苯二甲酸酯浓度调查，包括 11 户家庭、3 个实验室和 1 个医院。从通常用于清洁家庭、实验室和医院的真空吸尘器袋中收集灰尘样本。本研究的主要目的是确定卡塔尔灰尘中邻苯二甲酸酯的存在和浓度，从而估计非饮食人类暴露情况。分析了 11 种邻苯二甲酸酯。在卡塔尔家庭中，主要的邻苯二甲酸酯化合物为未标记的邻苯二甲酸二（2-乙基己基）酯（DEHP）和邻苯二甲酸二异壬酯（DINP），几何平均值分别为 288μg/g（中位数 395μg/g）和 106μg/g（中位数 101μg/g），分别占总测量邻苯二甲酸酯的 57%和 23%。在第一座实验室建筑中发现的主要邻苯二甲酸酯化合物为 DEHP 和 DINP，中位数分别为 4861μg/g 和 943μg/g，分别占总邻苯二甲酸酯的 82%和 16%。对于第二座实验室建筑，主要的邻苯二甲酸酯是 DEHP，中位数为 466μg/g，占所测邻苯二甲酸酯总量的 20%，DINP 的中位数为 1725μg/g，占所测邻苯二甲酸酯总量的 71%。从医院建筑中测试的灰尘样本中，DEHP 是主要的邻苯二甲酸酯化合物，中位数为 793μg/g，占所测邻苯二甲酸酯总量的 4.0%，DINP 的中位数为 19626μg/g，占所测邻苯二甲酸酯总量的 94%。根据邻苯二甲酸酯浓度（中位数），对儿童、成人和幼儿的非饮食性人类暴露进行了估计，结果分别为儿童 225ng/kg bw/day、成人 2328ng/kg bw/day 和幼儿 2099ng/kg bw/day。
