Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China Institute of Technology, Nanchang, Jiangxi Province, PR China.
Talanta. 2011 Sep 15;85(3):1665-71. doi: 10.1016/j.talanta.2011.06.070. Epub 2011 Jul 3.
High throughput analysis of sunscreen agents present in cream cosmetic has been demonstrated, typically 2 samples per minute, using neutral desorption extractive electrospray ionization mass spectrometry (ND-EESI-MS) without sample pretreatment. For the targeted compounds such as 4-Aminobenzoic acid and oxybenzone, ND-EESI-MS method provided linear signal responses in the range of 1-100 ppb. Limits of detection (LOD) of the method were estimated at sub-ppb levels for the analytes tested. Reasonable relative standard deviation (RSD=8.4-16.0%) was obtained as a result of 10 independent measurements for commercial cosmetics samples spiked with each individual sunscreen agents at 1-10 ppb. Acceptable recoveries were achieved in the range of 87-116% for direct analysis of commercial cream cosmetic samples. The experimental data demonstrate that ND-EESI-MS is a useful tool for high throughput screening of sunscreen agents in highly viscous cream cosmetic products, with the capability to obtain quantitative information of the analytes.
已经证明，使用中性解吸提取电喷雾电离质谱（ND-EESI-MS），无需样品预处理，即可对乳膏化妆品中的防晒剂进行高通量分析，通常每分钟可分析 2 个样品。对于 4-氨基苯甲酸和氧苯酮等目标化合物，ND-EESI-MS 方法在 1-100 ppb 的范围内提供了线性信号响应。该方法对测试的分析物的检测限（LOD）估计在亚 ppb 水平。对商业化妆品样品进行 10 次独立测量，在 1-10 ppb 范围内对每种单独的防晒剂进行加标，得到了合理的相对标准偏差（RSD=8.4-16.0%）。对于商业乳膏化妆品样品的直接分析，可获得 87-116%的可接受回收率。实验数据表明，ND-EESI-MS 是一种用于高度粘稠乳膏化妆品产品中防晒剂高通量筛选的有用工具，具有获得分析物定量信息的能力。
