Valdivielso José M, Coll Blai, Fernandez Elvira
Hospital Universitario Arnau de Vilanova, Experimental Nephrology Laboratory, Spain.
Expert Opin Ther Targets. 2009 Jan;13(1):29-38. doi: 10.1517/14728220802564390.
Vitamin D is a steroid hormone known for its role in regulating levels of calcium and phosphorus. Vitamin D has important autocrine/paracrine roles and it is involved in vascular biology. Clinical studies have shown a relationship between vitamin D levels and cardiovascular health, and low levels of vitamin D metabolites have been associated with higher incidence of congestive heart failure and increases in mortality.
To summarise the effect of vitamin D on cardiovascular pathology, the leading cause of death in chronic kidney disease patients.
All results indicate a potential effect of vitamin D on cardiovascular health. Therefore, maintaining optimum levels of circulating vitamin D is critical for a healthy cardiovascular system. In patients with low vitamin D status, like renal patients, supplementation with vitamin D metabolites has shown beneficial cardiovascular effects.
维生素D是一种类固醇激素，以其在调节钙和磷水平方面的作用而闻名。维生素D具有重要的自分泌/旁分泌作用，并且参与血管生物学过程。临床研究表明维生素D水平与心血管健康之间存在关联，维生素D代谢物水平低与充血性心力衰竭发病率较高及死亡率增加有关。
总结维生素D对慢性肾病患者主要死因——心血管病理的影响。
所有结果均表明维生素D对心血管健康具有潜在影响。因此，维持循环维生素D的最佳水平对健康的心血管系统至关重要。在维生素D水平低的患者（如肾病患者）中，补充维生素D代谢物已显示出有益的心血管作用。
