Liu Ai-dong, Hou Wei, Chen Xue-song, Qiu Zhi-dong
Department of Cardiology, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin Province 130021, China.
Zhong Xi Yi Jie He Xue Bao. 2008 Dec;6(12):1286-9. doi: 10.3736/jcim20081215.
To extract praeruptorin A from Radix Peucedani by supercritical fluid extraction (SFE)-CO2.
After preliminary experiment, three main factors were acquired that could influence the result of SFE-CO2, including the time, pressure and temperature of the extraction. The optimal extraction process was carried out on orthogonal design, and SFE-CO2 was compared with the traditional methods.
In the extraction of the praeruptorin A, the best extraction conditions were 60 degrees C, 20 MPa, and duration for three hours. As cosolvent alcohol was added, the amount of extraction of the praeruptorin A increased, and the amount of SFE-CO2 extraction was higher than those of decoction and heating reflux.
The SFE-CO2 in extracting praeruptorin A from Radix Peucedani is feasible and reliable.
采用超临界流体萃取（SFE）-CO₂法从杭白芷中提取前胡素A。
经过初步实验，获得了影响SFE-CO₂结果的三个主要因素，包括萃取时间、压力和温度。采用正交设计进行最佳萃取工艺，并将SFE-CO₂与传统方法进行比较。
在前胡素A的萃取中，最佳萃取条件为60℃、20MPa、持续3小时。加入共溶剂乙醇后，前胡素A的萃取量增加，SFE-CO₂的萃取量高于水煎法和加热回流法。
SFE-CO₂法从杭白芷中提取前胡素A是可行且可靠的。
