Hooper P, Bora N S, Kaplan H J, Ferguson T A
Department of Ophthalmology, Washington University School of Medicine, St. Louis, MO 63110.
Curr Eye Res. 1991 Apr;10(4):363-72. doi: 10.3109/02713689108996342.
The mechanisms by which the eye maintains an immunosuppressive environment has been the subject of recent investigations. In this report we investigated the ability of resident ocular cells from the iris, choroid, and retina to inhibit lymphocyte responses in vitro. Our results demonstrate that single cell suspensions derived from iris and choroid to inhibit alloantigen induced lymphocyte proliferation. We show that this inhibition was mediated by soluble factors which are low (less than 10,000) and intermediate (10,000-30,000) molecular weight molecules. This capacity is limited to iris and choroid and is not demonstrable in cell preparations derived from the retina. We conclude from our studies that cells derived from iris and choroid are capable of regulating immune responses and suggest that these cells (or their soluble products) may play a role in the immunosuppressive environment of the eye.
眼睛维持免疫抑制环境的机制一直是近期研究的主题。在本报告中，我们研究了来自虹膜、脉络膜和视网膜的眼部常驻细胞在体外抑制淋巴细胞反应的能力。我们的结果表明，来自虹膜和脉络膜的单细胞悬液能够抑制同种异体抗原诱导的淋巴细胞增殖。我们发现这种抑制是由低分子量（小于10,000）和中等分子量（10,000 - 30,000）的可溶性因子介导的。这种能力仅限于虹膜和脉络膜，在源自视网膜的细胞制剂中未得到证实。我们从研究中得出结论，来自虹膜和脉络膜的细胞能够调节免疫反应，并表明这些细胞（或其可溶性产物）可能在眼睛的免疫抑制环境中发挥作用。
